m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00092
 [1], [2], [3], [4], [5]
m6A modification ADAR1 ADAR1 METTL3 Methylation : m6A sites Direct Enhancement RNA modification GLI1 GLI1 ADAR Methylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Interferon-inducible protein 4 (ADAR1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target Zinc finger protein GLI1 (GLI1) View Details
Crosstalk Relationship m6A  →  A-to-I Enhancement
Crosstalk Mechanism m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Zinc finger protein GLI1 (GLI1) transcript.
Responsed Drug PMID26666870-Compound-16
 Drug Info 
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model
 MGG8 Glioblastoma Homo sapiens CVCL_D1H4
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-118MG Astrocytoma Homo sapiens CVCL_0633
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
NCI-H929 Plasma cell myeloma Homo sapiens CVCL_1600
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Zinc finger protein GLI1 (GLI1) 12 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PMID26666870-Compound-16 Patented [6]
MOA Inhibitor
External Link
TTD: D00KXJ
 Compound Name Imidazo bicyclic iminium derivative 1 Patented [6]
Synonyms
PMID26666870-Compound-17
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MOA Inhibitor
External Link
TTD: D0FL0T
 Compound Name Imidazo bicyclic iminium derivative 2 Patented [6]
Synonyms
PMID26666870-Compound-18
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MOA Inhibitor
External Link
TTD: D0II7X
 Compound Name Isoflavone derivative 1 Patented [6]
Synonyms
PMID26666870-Compound-19
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MOA Inhibitor
External Link
TTD: D00RRB
 Compound Name Isoflavone derivative 5 Patented [6]
Synonyms
PMID26666870-Compound-23
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MOA Inhibitor
External Link
TTD: D01BGG
 Compound Name Isoflavone derivative 7 Patented [6]
Synonyms
PMID26666870-Compound-25
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MOA Inhibitor
External Link
TTD: D04IFL
 Compound Name Isoflavone derivative 8 Patented [6]
Synonyms
PMID26666870-Compound-26
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MOA Inhibitor
External Link
TTD: D05NRG
 Compound Name Isoflavone derivative 9 Patented [6]
Synonyms
PMID26666870-Compound-27
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MOA Inhibitor
External Link
TTD: D09VIE
 Compound Name Isoflavone derivative 6 Patented [6]
Synonyms
PMID26666870-Compound-24
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MOA Inhibitor
External Link
TTD: D0J1RB
 Compound Name Isoflavone derivative 3 Patented [6]
Synonyms
PMID26666870-Compound-21
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MOA Inhibitor
External Link
TTD: D0TP0S
 Compound Name Isoflavone derivative 2 Patented [6]
Synonyms
PMID26666870-Compound-20
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MOA Inhibitor
External Link
TTD: D0WI1G
 Compound Name Isoflavone derivative 4 Patented [6]
Synonyms
PMID26666870-Compound-22
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MOA Inhibitor
External Link
TTD: D0Z6IS
References
Ref 1 N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2 ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism. Genome Biol. 2021 Jan 28;22(1):51. doi: 10.1186/s13059-021-02271-9.
Ref 3 RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling. RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.
Ref 4 Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun. 2017 Dec 4;8(1):1922. doi: 10.1038/s41467-017-01890-w.
Ref 5 CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing. Mol Cancer. 2021 Mar 9;20(1):51. doi: 10.1186/s12943-021-01333-7.
Ref 6 Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35.