Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00048)
Target Name Zinc finger protein GLI1 (GLI1)
Synonyms
Glioma-associated oncogene; Oncogene GLI; GLI
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Gene Name GLI1
Sequence
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETNSCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA
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Family GLI C2H2-type zinc-finger protein family
Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
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Gene ID 2735
HGNC ID HGNC:4317
Ensembl Gene ID ENSG00000111087
KEGG ID hsa:2735
Chromosomal Location 12q13.3
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00048)
Zinc finger protein GLI1 (GLI1)
Adenosine-to-Inosine editing (A-to-I)
In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005629 Click to Show/Hide the Full List
mod site chr12:57470840-57470841:+ [1]
Sequence AGAATGCTGCCATGGATGCTAGAGGGCTACAGGAAGAGCCA
Transcript ID List ENST00000228682.7; ENST00000543426.5; ENST00000546141.5; ENST00000528467.1
External Link RMBase: RNA-editing_site_29456
N6-methyladenosine (m6A)
In total 34 m6A sequence/site(s) in this target gene
mod ID: M6ASITE013560 Click to Show/Hide the Full List
mod site chr12:57464759-57464760:+ [2]
Sequence TCTGTCGGATGCCAGCCTGGACCTGCAGACGGTTATCCGCA
Motif Score 3.622404762
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000543426.5; ENST00000532291.5; ENST00000528467.1; ENST00000546141.5; ENST00000228682.7; ENST00000528432.1; ENST00000530789.1
External Link RMBase: m6A_site_195033
mod ID: M6ASITE013561 Click to Show/Hide the Full List
mod site chr12:57464939-57464940:+ [2]
Sequence TAAAAGTCTCAAGCCCTCAAACTACCTAACCCTATTTGAAT
Motif Score 2.627720238
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000530789.1; ENST00000528467.1; ENST00000228682.7; ENST00000546141.5; ENST00000543426.5; ENST00000532291.5
External Link RMBase: m6A_site_195034
mod ID: M6ASITE013562 Click to Show/Hide the Full List
mod site chr12:57466358-57466359:+ [3]
Sequence CTGGTGGTTCACATGCGCAGACACACTGGCGAGAAGCCACA
Motif Score 2.897386905
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000546141.5; ENST00000532291.5; ENST00000543426.5; ENST00000528467.1; ENST00000228682.7
External Link RMBase: m6A_site_195035
mod ID: M6ASITE013563 Click to Show/Hide the Full List
mod site chr12:57467369-57467370:+ [3]
Sequence GTCATACTCACGCCTCGAAAACCTGAAGACGCACCTGCGGT
Motif Score 2.185083333
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000528467.1; ENST00000228682.7; ENST00000543426.5; ENST00000546141.5
External Link RMBase: m6A_site_195036
mod ID: M6ASITE013564 Click to Show/Hide the Full List
mod site chr12:57468199-57468200:+ [3]
Sequence CCCATCAGGGAGGAAAGCAGACTGACTGTGCCAGAGGGTGC
Motif Score 3.319380952
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000546141.5; ENST00000528467.1; ENST00000228682.7; ENST00000543426.5
External Link RMBase: m6A_site_195037
mod ID: M6ASITE013565 Click to Show/Hide the Full List
mod site chr12:57469506-57469507:+ [4]
Sequence AGGGAGTGCAGCCAATACAGACAGTGGTGTGGAAATGACTG
Motif Score 2.897386905
Cell/Tissue List H1A; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000546141.5; ENST00000228682.7; ENST00000543426.5; ENST00000528467.1
External Link RMBase: m6A_site_195038
mod ID: M6ASITE013566 Click to Show/Hide the Full List
mod site chr12:57469551-57469552:+ [4]
Sequence TGCAGGGGGCAGCACTGAAGACCTCTCCAGCTTGGACGAGG
Motif Score 2.876744048
Cell/Tissue List H1A; H1B; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000528467.1; ENST00000543426.5; ENST00000228682.7; ENST00000546141.5
External Link RMBase: m6A_site_195039
mod ID: M6ASITE013567 Click to Show/Hide the Full List
mod site chr12:57469573-57469574:+ [4]
Sequence CTCTCCAGCTTGGACGAGGGACCTTGCATTGCTGGCACTGG
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000546141.5; ENST00000543426.5; ENST00000228682.7; ENST00000528467.1
External Link RMBase: m6A_site_195040
mod ID: M6ASITE013568 Click to Show/Hide the Full List
mod site chr12:57469620-57469621:+ [4]
Sequence CACTCTTCGCCGCCTTGAGAACCTCAGGCTGGACCAGCTAC
Motif Score 2.930744048
Cell/Tissue List H1A; H1B; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000528467.1; ENST00000228682.7; ENST00000546141.5; ENST00000543426.5
External Link RMBase: m6A_site_195041
mod ID: M6ASITE013569 Click to Show/Hide the Full List
mod site chr12:57469632-57469633:+ [4]
Sequence CCTTGAGAACCTCAGGCTGGACCAGCTACATCAACTCCGGC
Motif Score 3.622404762
Cell/Tissue List H1A; H1B; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000228682.7; ENST00000543426.5; ENST00000546141.5; ENST00000528467.1
External Link RMBase: m6A_site_195042
mod ID: M6ASITE013570 Click to Show/Hide the Full List
mod site chr12:57469661-57469662:+ [4]
Sequence ATCAACTCCGGCCAATAGGGACCCGGGGTCTCAAACTGCCC
Motif Score 3.622404762
Cell/Tissue List H1A; GSC-11; endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000543426.5; ENST00000546141.5; ENST00000528467.1; ENST00000228682.7
External Link RMBase: m6A_site_195043
mod ID: M6ASITE013571 Click to Show/Hide the Full List
mod site chr12:57469675-57469676:+ [3]
Sequence ATAGGGACCCGGGGTCTCAAACTGCCCAGCTTGTCCCACAC
Motif Score 2.627720238
Cell/Tissue List endometrial
Seq Type List m6A-seq
Transcript ID List ENST00000546141.5; ENST00000528467.1; ENST00000543426.5; ENST00000228682.7
External Link RMBase: m6A_site_195044
mod ID: M6ASITE013572 Click to Show/Hide the Full List
mod site chr12:57470758-57470759:+ [5]
Sequence CCCACTGTGGCAGGGGGAGGACAGAACTTTGATCCTTACCT
Motif Score 3.643047619
Cell/Tissue List A549; U2OS; H1B; hESCs; GSC-11; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000543426.5; ENST00000546141.5; ENST00000528467.1; ENST00000228682.7
External Link RMBase: m6A_site_195045
mod ID: M6ASITE013573 Click to Show/Hide the Full List
mod site chr12:57470763-57470764:+ [5]
Sequence TGTGGCAGGGGGAGGACAGAACTTTGATCCTTACCTCCCAA
Motif Score 3.373380952
Cell/Tissue List A549; U2OS; H1B; hESCs; GSC-11; endometrial
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000228682.7; ENST00000546141.5; ENST00000528467.1; ENST00000543426.5
External Link RMBase: m6A_site_195046
mod ID: M6ASITE013574 Click to Show/Hide the Full List
mod site chr12:57470870-57470871:+ [6]
Sequence AGGAAGAGCCAGAAGTTGGGACCTCCATGGTGGGCAGTGGT
Motif Score 3.622404762
Cell/Tissue List HeLa; A549; U2OS; H1A; H1B; hESCs; peripheral-blood; GSC-11; HEK293A-TOA; MSC; endometrial; HEC-1-A; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000543426.5; ENST00000228682.7; ENST00000546141.5; ENST00000528467.1
External Link RMBase: m6A_site_195047
mod ID: M6ASITE013575 Click to Show/Hide the Full List
mod site chr12:57470895-57470896:+ [6]
Sequence CATGGTGGGCAGTGGTCTGAACCCCTATATGGACTTCCCAC
Motif Score 2.930744048
Cell/Tissue List HeLa; A549; U2OS; H1A; H1B; hESCs; peripheral-blood; GSC-11; HEK293A-TOA; MSC; endometrial; HEC-1-A; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000228682.7; ENST00000546141.5; ENST00000543426.5; ENST00000528467.1
External Link RMBase: m6A_site_195048
mod ID: M6ASITE013576 Click to Show/Hide the Full List
mod site chr12:57470907-57470908:+ [6]
Sequence TGGTCTGAACCCCTATATGGACTTCCCACCTACTGATACTC
Motif Score 4.065041667
Cell/Tissue List HeLa; A549; U2OS; H1A; H1B; hESCs; peripheral-blood; GSC-11; HEK293A-TOA; MSC; endometrial; HEC-1-A; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000228682.7; ENST00000546141.5; ENST00000543426.5; ENST00000528467.1
External Link RMBase: m6A_site_195049
mod ID: M6ASITE013577 Click to Show/Hide the Full List
mod site chr12:57470941-57470942:+ [6]
Sequence GATACTCTGGGATATGGGGGACCTGAAGGGGCAGCAGCTGA
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; U2OS; H1A; H1B; hESCs; peripheral-blood; GSC-11; HEK293A-TOA; MSC; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000528467.1; ENST00000546141.5; ENST00000228682.7; ENST00000543426.5
External Link RMBase: m6A_site_195050
mod ID: M6ASITE013578 Click to Show/Hide the Full List
mod site chr12:57471074-57471075:+ [5]
Sequence ATCCTGACCCCACCCAAGAAACATGGGGTGAGTTCCCTTCC
Motif Score 2.20572619
Cell/Tissue List HEK293T; A549; U2OS; H1A; H1B; hESCs; GSC-11; TREX; endometrial; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000228682.7; ENST00000528467.1; ENST00000546141.5; ENST00000543426.5
External Link RMBase: m6A_site_195051
mod ID: M6ASITE013579 Click to Show/Hide the Full List
mod site chr12:57471134-57471135:+ [5]
Sequence GCCCCAAGGCTCTAGGTGGAACCTACAGCCAGTGTCCTCGA
Motif Score 2.930744048
Cell/Tissue List A549; HEK293T; U2OS; H1A; H1B; hESCs; Huh7; GSC-11; HEK293A-TOA; TREX; endometrial; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000543426.5; ENST00000528467.1; ENST00000228682.7; ENST00000546141.5
External Link RMBase: m6A_site_195052
mod ID: M6ASITE013580 Click to Show/Hide the Full List
mod site chr12:57471160-57471161:+ [5]
Sequence AGCCAGTGTCCTCGACTTGAACATTATGGACAAGTGCAAGT
Motif Score 2.951386905
Cell/Tissue List A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TREX; endometrial; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000228682.7; ENST00000528467.1; ENST00000546141.5; ENST00000543426.5
External Link RMBase: m6A_site_195053
mod ID: M6ASITE013581 Click to Show/Hide the Full List
mod site chr12:57471169-57471170:+ [5]
Sequence CCTCGACTTGAACATTATGGACAAGTGCAAGTCAAGCCAGA
Motif Score 3.643047619
Cell/Tissue List A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TREX; endometrial; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000528467.1; ENST00000543426.5; ENST00000546141.5; ENST00000228682.7
External Link RMBase: m6A_site_195054
mod ID: M6ASITE013582 Click to Show/Hide the Full List
mod site chr12:57471190-57471191:+ [5]
Sequence CAAGTGCAAGTCAAGCCAGAACAGGGGTGCCCAGTGGGGTC
Motif Score 2.951386905
Cell/Tissue List A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TREX; endometrial; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000528467.1; ENST00000546141.5; ENST00000543426.5; ENST00000228682.7
External Link RMBase: m6A_site_195055
mod ID: M6ASITE013583 Click to Show/Hide the Full List
mod site chr12:57471223-57471224:+ [5]
Sequence GTGGGGTCTGACTCCACAGGACTGGCACCCTGCCTCAATGC
Motif Score 4.065041667
Cell/Tissue List A549; HEK293T; U2OS; H1A; H1B; hESCs; GM12878; Huh7; GSC-11; HEK293A-TOA; MSC; TREX; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000528467.1; ENST00000546141.5; ENST00000228682.7; ENST00000543426.5
External Link RMBase: m6A_site_195056
mod ID: M6ASITE013584 Click to Show/Hide the Full List
mod site chr12:57471367-57471368:+ [5]
Sequence CCTGATTATCTTCCTTCAGAACCCAGGCCTTGCCTGGACTT
Motif Score 2.930744048
Cell/Tissue List A549; Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000546141.5; ENST00000228682.7; ENST00000543426.5; ENST00000528467.1
External Link RMBase: m6A_site_195057
mod ID: M6ASITE013585 Click to Show/Hide the Full List
mod site chr12:57471384-57471385:+ [5]
Sequence AGAACCCAGGCCTTGCCTGGACTTTGATTCCCCCACCCATT
Motif Score 4.065041667
Cell/Tissue List A549; Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000543426.5; ENST00000546141.5; ENST00000528467.1; ENST00000228682.7
External Link RMBase: m6A_site_195058
mod ID: M6ASITE013586 Click to Show/Hide the Full List
mod site chr12:57471586-57471587:+ [2]
Sequence GCTCCAGTGAACACATATGGACCTGGCTTTGGACCCAACTT
Motif Score 3.622404762
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000543426.5; ENST00000528467.1; ENST00000546141.5; ENST00000228682.7
External Link RMBase: m6A_site_195059
mod ID: M6ASITE013587 Click to Show/Hide the Full List
mod site chr12:57471598-57471599:+ [2]
Sequence ACATATGGACCTGGCTTTGGACCCAACTTGCCCAATCACAA
Motif Score 3.622404762
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000228682.7; ENST00000528467.1; ENST00000543426.5; ENST00000546141.5
External Link RMBase: m6A_site_195060
mod ID: M6ASITE013588 Click to Show/Hide the Full List
mod site chr12:57471762-57471763:+ [6]
Sequence TCTCAAAGTGGGAGGCACAAACCCCAGCTGTGGTCATCCTG
Motif Score 2.185083333
Cell/Tissue List HeLa; U2OS; A549
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000543426.5; ENST00000546141.5; ENST00000528467.1; ENST00000228682.7
External Link RMBase: m6A_site_195061
mod ID: M6ASITE013589 Click to Show/Hide the Full List
mod site chr12:57471832-57471833:+ [6]
Sequence TTGTACCCTCCTCCCGAAGGACAGGTATGTAACCCCCTGGA
Motif Score 3.643047619
Cell/Tissue List HeLa; A549; U2OS; H1A; H1B; hESCs; GSC-11; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000546141.5; ENST00000528467.1; ENST00000228682.7; ENST00000543426.5
External Link RMBase: m6A_site_195062
mod ID: M6ASITE013590 Click to Show/Hide the Full List
mod site chr12:57471852-57471853:+ [6]
Sequence ACAGGTATGTAACCCCCTGGACTCTCTTGATCTTGACAACA
Motif Score 4.065041667
Cell/Tissue List HeLa; HEK293T; A549; U2OS; H1A; H1B; hESCs; GSC-11; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000546141.5; ENST00000228682.7; ENST00000543426.5; ENST00000528467.1
External Link RMBase: m6A_site_195063
mod ID: M6ASITE013591 Click to Show/Hide the Full List
mod site chr12:57471882-57471883:+ [6]
Sequence TCTTGACAACACTCAGCTGGACTTTGTGGCTATTCTGGATG
Motif Score 4.065041667
Cell/Tissue List HeLa; HEK293T; A549; H1A; H1B; hESCs; GSC-11; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000228682.7; ENST00000543426.5; ENST00000528467.1; ENST00000546141.5
External Link RMBase: m6A_site_195064
mod ID: M6ASITE013592 Click to Show/Hide the Full List
mod site chr12:57471955-57471956:+ [5]
Sequence GATCAGCGGGGCAGCTCTGGACATACCCCACCTCCCTCTGG
Motif Score 3.643047619
Cell/Tissue List HEK293T; A549; H1A; H1B; GSC-11; TREX; endometrial; HEC-1-A
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000228682.7; ENST00000543426.5; ENST00000528467.1; ENST00000546141.5
External Link RMBase: m6A_site_195065
mod ID: M6ASITE013593 Click to Show/Hide the Full List
mod site chr12:57472034-57472035:+ [5]
Sequence TGAGATCCCTACCTGGGGAAACAGAATTCCTCAACTCTAGT
Motif Score 2.20572619
Cell/Tissue List A549; H1B; GSC-11
Seq Type List MeRIP-seq; m6A-seq
Transcript ID List ENST00000543426.5; ENST00000228682.7; ENST00000528467.1; ENST00000546141.5
External Link RMBase: m6A_site_195066