m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00802)
Target Name Spectrin beta, non-erythrocytic 2 (SPTBN2)
Synonyms
Spectrin beta chain, non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein; KIAA0302; SCA5
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Gene Name SPTBN2
Chromosomal Location 11q13.2
Family Spectrin family
Function
Probably plays an important role in neuronal membrane skeleton.
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Gene ID 6712
Uniprot ID
SPTN2_HUMAN
HGNC ID
HGNC:11276
Ensembl Gene ID
ENSG00000173898
KEGG ID
hsa:6712
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SPTBN2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -1.19E+00
p-value: 2.92E-45
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Overexpression of LINC01605, regulated by SMYD2-EP300-mediated H3K27ac and H3K4me3 modifications, bound to METTL3 protein to promote m6A modification of Spectrin beta, non-erythrocytic 2 (SPTBN2) mRNA, leading to the development of colorectal cancer.
Target Regulation Up regulation
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Cell Process Cell proliferation and metastasis
Cell apoptosis
In-vitro Model Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
LoVo Colon adenocarcinoma Homo sapiens CVCL_0399
In-vivo Model The growth of CC cells in vivo was examined by subcutaneous injection of LoVo cells or Caco-2 cells into NSG mice, while the metastatic ability of cells in vivo by intracardiac injection into mice.
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Overexpression of LINC01605, regulated by SMYD2-EP300-mediated H3K27ac and H3K4me3 modifications, bound to METTL3 protein to promote m6A modification of Spectrin beta, non-erythrocytic 2 (SPTBN2) mRNA, leading to the development of colorectal cancer.
Responsed Disease Colorectal cancer [ICD-11: 2B91]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation and metastasis
Cell apoptosis
In-vitro Model Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
LoVo Colon adenocarcinoma Homo sapiens CVCL_0399
In-vivo Model The growth of CC cells in vivo was examined by subcutaneous injection of LoVo cells or Caco-2 cells into NSG mice, while the metastatic ability of cells in vivo by intracardiac injection into mice.
References
Ref 1 LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer. Cancer Cell Int. 2021 Sep 20;21(1):504. doi: 10.1186/s12935-021-02180-8.