m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00782)
Target Name Yes tyrosine kinase (YES/YES1)
Synonyms
YES; Tyrosine-protein kinase Yes; EC 2.7.10.2 ; Proto-oncogene c-Yes ; p61-Yes
    Click to Show/Hide
Gene Name YES1
Chromosomal Location 18p11.32
Family Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
Function
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
    Click to Show/Hide
Gene ID 7525
Uniprot ID
YES_HUMAN
HGNC ID
HGNC:12841
Ensembl Gene ID
ENSG00000176105.14
KEGG ID
hsa:7525
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
YES1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA-binding motif protein 15 (RBM15) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary RBM15-mediated m6A modification contributed to a post-transcriptional activation of Yes tyrosine kinase (YES/YES1) in an IGF2BP1-dependent manner. RBM15-mediated m6A modification facilitate the progression of HCC via the IGF2BP1-YES1-MAPK axis.
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Pathway Response MAPK signaling pathway hsa04010
In-vitro Model HCC-LM3 (HCC-LM3 were obtained from Guangzhou Cellcook Biotech Co., Ltd.)
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
B76.1/Huh7 Adult hepatocellular carcinoma Homo sapiens CVCL_U443
In-vivo Model 5 × 106 Huh7 and HCC-LM3 cells resuspended in 100ul PBS were subcutaneously injected to the left flank of the mice (randomly selected, five mice per group for Huh7 cells in the first time and ten mice per group for HCC-LM3 cells in the second time. No blinding was performed).
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary RBM15-mediated m6A modification contributed to a post-transcriptional activation of Yes tyrosine kinase (YES/YES1) in an IGF2BP1-dependent manner. RBM15-mediated m6A modification facilitate the progression of HCC via the IGF2BP1-YES1-MAPK axis.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator RNA-binding motif protein 15 (RBM15) WRITER
 Regulator Info 
Pathway Response MAPK signaling pathway hsa04010
In-vitro Model HCC-LM3 (HCC-LM3 were obtained from Guangzhou Cellcook Biotech Co., Ltd.)
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
B76.1/Huh7 Adult hepatocellular carcinoma Homo sapiens CVCL_U443
In-vivo Model 5 × 106 Huh7 and HCC-LM3 cells resuspended in 100ul PBS were subcutaneously injected to the left flank of the mice (randomly selected, five mice per group for Huh7 cells in the first time and ten mice per group for HCC-LM3 cells in the second time. No blinding was performed).
References
Ref 1 RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner. Cell Death Discov. 2021 Oct 27;7(1):315. doi: 10.1038/s41420-021-00703-w.