m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00779)
Target Name Serine/arginine-rich splicing factor 7 (SRSF7)
Synonyms
SFRS7; Serine/arginine-rich splicing factor 7 ; Splicing factor 9G8 ; Splicing factor; arginine/serine-rich 7
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Gene Name SRSF7
Chromosomal Location 2p22.1
Family Splicing factor SR family
Function
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
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Gene ID 6432
Uniprot ID
SRSF7_HUMAN
HGNC ID
HGNC:10789
Ensembl Gene ID
ENSG00000115875.19
KEGG ID
hsa:6432
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SRSF7 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between SRSF7 and the regulator
Cell Line HEK293T Homo sapiens
Regulation logFC: 1.26E+00 GSE90639
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The gene expression of Serine/arginine-rich splicing factor 7 (SRSF7) is positively correlated with glioblastoma (GBM) cell-specific m6A methylation. The two m6A sites on PDZ-binding kinase (PBK) are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by IGF2BP2.
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response Spliceosome hsa03040
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
U87MG (Astroblastoma cells from human brain)
LN-229 Glioblastoma Homo sapiens CVCL_0393
A-172 Glioblastoma Homo sapiens CVCL_0131
LN-18 Glioblastoma Homo sapiens CVCL_0392
LN-428 Glioblastoma Homo sapiens CVCL_3959
LN-443 Glioblastoma Homo sapiens CVCL_3960
SNB-19 Astrocytoma Homo sapiens CVCL_0535
T98G Glioblastoma Homo sapiens CVCL_0556
U-118MG Astrocytoma Homo sapiens CVCL_0633
U251 (Fibroblasts or fibroblast like cells)
U-138MG Astrocytoma Homo sapiens CVCL_0020
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The gene expression of Serine/arginine-rich splicing factor 7 (SRSF7) is positively correlated with glioblastoma (GBM) cell-specific m6A methylation. The two m6A sites on PDZ-binding kinase (PBK) are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by IGF2BP2.
Responsed Disease Glioblastoma [ICD-11: 2A00.00]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Pathway Response Spliceosome hsa03040
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
U87MG (Astroblastoma cells from human brain)
LN-229 Glioblastoma Homo sapiens CVCL_0393
A-172 Glioblastoma Homo sapiens CVCL_0131
LN-18 Glioblastoma Homo sapiens CVCL_0392
LN-428 Glioblastoma Homo sapiens CVCL_3959
LN-443 Glioblastoma Homo sapiens CVCL_3960
SNB-19 Astrocytoma Homo sapiens CVCL_0535
T98G Glioblastoma Homo sapiens CVCL_0556
U-118MG Astrocytoma Homo sapiens CVCL_0633
U251 (Fibroblasts or fibroblast like cells)
U-138MG Astrocytoma Homo sapiens CVCL_0020
References
Ref 1 Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma. Genomics Proteomics Bioinformatics. 2021 Dec 23:S1672-0229(21)00252-7. doi: 10.1016/j.gpb.2021.11.001. Online ahead of print.