m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00758)
Target Name Protein BTG2 (BTG2)
Synonyms
PC3; Protein BTG2 ; BTG family member 2 ; NGF-inducible anti-proliferative protein PC3
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Gene Name BTG2
Chromosomal Location 1q32.1
Family BTG family
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
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Gene ID 7832
Uniprot ID
BTG2_HUMAN
HGNC ID
HGNC:1131
Ensembl Gene ID
ENSG00000159388.6
KEGG ID
hsa:7832
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
BTG2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Protein virilizer homolog (VIRMA) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Knockdown of KIAA1429 significantly decreased the m6A levels of Protein BTG2 (BTG2) mRNA, leading to enhanced YTHDF2-dependent BTG2 mRNA stability and promoted the expression of BTG2; thus, participating in the tumorigenesis of LUAD.
Target Regulation Up regulation
Responsed Disease Lung adenocarcinoma ICD-11: 2C25.0
 Disease Info 
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
SPC-A1 Endocervical adenocarcinoma Homo sapiens CVCL_6955
NCI-H1299 Lung large cell carcinoma Homo sapiens CVCL_0060
HBE (Human bronchial epithelial cell line)
In-vivo Model For the in vivo cell proliferation assay, A549 and SPCA1 cells were stably transfected with sh-Ctrl and sh-KIAA1429 using lentivirus (GeneChem, Shanghai, China). The cells were subcutaneously injected into either side of the posterior flanks of the mouse. The tumor volume was measured every few days (length×width2×0.5).
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Knockdown of KIAA1429 significantly decreased the m6A levels of Protein BTG2 (BTG2) mRNA, leading to enhanced YTHDF2-dependent BTG2 mRNA stability and promoted the expression of BTG2; thus, participating in the tumorigenesis of LUAD.
Responsed Disease Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
SPC-A1 Endocervical adenocarcinoma Homo sapiens CVCL_6955
NCI-H1299 Lung large cell carcinoma Homo sapiens CVCL_0060
HBE (Human bronchial epithelial cell line)
In-vivo Model For the in vivo cell proliferation assay, A549 and SPCA1 cells were stably transfected with sh-Ctrl and sh-KIAA1429 using lentivirus (GeneChem, Shanghai, China). The cells were subcutaneously injected into either side of the posterior flanks of the mouse. The tumor volume was measured every few days (length×width2×0.5).
References
Ref 1 Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma. Cancer Commun (Lond). 2022 Jul;42(7):609-626. doi: 10.1002/cac2.12325. Epub 2022 Jun 21.