m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00755)
Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3)
Synonyms
Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3 ; Activating transcription factor 3
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Gene Name ATF3
Chromosomal Location 1q32.3
Family BZIP family, ATF subfamily
Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Stress-induced isoform, counteracts the transcriptional repression of isoform 1.
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Gene ID 467
Uniprot ID
ATF3_HUMAN
HGNC ID
HGNC:785
Ensembl Gene ID
ENSG00000162772.17
KEGG ID
hsa:467
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ATF3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The increased expression of Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) in tamoxifen-resistant cells arises from the decreased expression of the m6A reader protein YTHDF2 and the ensuing elevated stability of ATF3 mRNA, which ultimately promotes the translation of ATF3. ATF3 as a candidate therapeutic target for mitigating drug resistance in breast cancer cells.
Target Regulation Down regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
In-vitro Model MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
Breast cancer [ICD-11: 2C60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The increased expression of Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) in tamoxifen-resistant cells arises from the decreased expression of the m6A reader protein YTHDF2 and the ensuing elevated stability of ATF3 mRNA, which ultimately promotes the translation of ATF3. ATF3 as a candidate therapeutic target for mitigating drug resistance in breast cancer cells.
Responsed Disease Breast cancer [ICD-11: 2C60]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
References
Ref 1 ATF3 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an N(6)-Methyladenosine-Based Epitranscriptomic Mechanism. Chem Res Toxicol. 2021 Jul 19;34(7):1814-1821. doi: 10.1021/acs.chemrestox.1c00206. Epub 2021 Jul 2.