m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00754)
Target Name Melanoma-associated antigen D1 (MAGED1)
Synonyms
NRAGE; Melanoma-associated antigen D1 ; MAGE tumor antigen CCF ; MAGE-D1 antigen ; Neurotrophin receptor-interacting MAGE homolog
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Gene Name MAGED1
Chromosomal Location Xp11.22
Function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
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Gene ID 9500
Uniprot ID
MAGD1_HUMAN
HGNC ID
HGNC:6813
Ensembl Gene ID
ENSG00000179222.18
KEGG ID
hsa:9500
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MAGED1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 1 (YTHDF1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF1 promotes PASMC proliferation and pulmonary hypertension by enhancing Melanoma-associated antigen D1 (MAGED1) translation.
Target Regulation Up regulation
Responsed Disease Pulmonary hypertension ICD-11: BB01
 Disease Info 
In-vitro Model PASMC cell line (Pulmonary artery smooth muscle cell)
In-vivo Model SMC-specific TWIST1-deficient mice were generated by crossing TWIST1flox/flox mice with animals expressing Sm22-Cre (smooth muscle protein 22-Cre). Deletion of TWIST1 in SMCs was confirmed by histology and Western blot.
Pulmonary hypertension [ICD-11: BB01]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF1 promotes PASMC proliferation and pulmonary hypertension by enhancing Melanoma-associated antigen D1 (MAGED1) translation.
Responsed Disease Pulmonary hypertension [ICD-11: BB01]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model PASMC cell line (Pulmonary artery smooth muscle cell)
In-vivo Model SMC-specific TWIST1-deficient mice were generated by crossing TWIST1flox/flox mice with animals expressing Sm22-Cre (smooth muscle protein 22-Cre). Deletion of TWIST1 in SMCs was confirmed by histology and Western blot.
References
Ref 1 YTHDF1 Regulates Pulmonary Hypertension through Translational Control of MAGED1. Am J Respir Crit Care Med. 2021 May 1;203(9):1158-1172. doi: 10.1164/rccm.202009-3419OC.