m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00752)
Target Name G2/mitotic-specific cyclin-B2 (CCNB2)
Gene Name CCNB2
Chromosomal Location 15q22.2
Family Cyclin family, Cyclin AB subfamily
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
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Gene ID 9133
Uniprot ID
CCNB2_HUMAN
HGNC ID
HGNC:1580
Ensembl Gene ID
ENSG00000157456
KEGG ID
hsa:9133
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CCNB2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 2 (YTHDC2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Over-expression (OE) of YTHDC2 increased G2/mitotic-specific cyclin-B2 (CCNB2) levels, reduced cell cycle arrest, and improved reproductive toxicity after Mn exposure.
Target Regulation Up regulation
Responsed Disease Male infertility ICD-11: GB04
 Disease Info 
Pathway Response Cell cycle hsa04110
Cell Process Block the G2/M phase
In-vitro Model GC-1 spg Normal Mus musculus CVCL_8872
In-vivo Model Mice in the control group received an i.p. injections of 0.9% NaCl. Mice in the low, medium, and high Mn groups received i.p. injections of 12.5, 25, and 50 mg/kg MnCl2. The volume of administration was 5 mL/kg body weight. The injection was given daily for 2 weeks.
Male infertility [ICD-11: GB04]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Over-expression (OE) of YTHDC2 increased G2/mitotic-specific cyclin-B2 (CCNB2) levels, reduced cell cycle arrest, and improved reproductive toxicity after Mn exposure.
Responsed Disease Male infertility [ICD-11: GB04]
Target Regulator YTH domain-containing protein 2 (YTHDC2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cell cycle hsa04110
Cell Process Block the G2/M phase
In-vitro Model GC-1 spg Normal Mus musculus CVCL_8872
In-vivo Model Mice in the control group received an i.p. injections of 0.9% NaCl. Mice in the low, medium, and high Mn groups received i.p. injections of 12.5, 25, and 50 mg/kg MnCl2. The volume of administration was 5 mL/kg body weight. The injection was given daily for 2 weeks.
References
Ref 1 Protective role of m(6)A binding protein YTHDC2 on CCNB2 in manganese-induced spermatogenesis dysfunction. Chem Biol Interact. 2022 Jan 5;351:109754. doi: 10.1016/j.cbi.2021.109754. Epub 2021 Nov 22.