m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00750)
Target Name Adenomatous polyposis coli protein (APC)
Synonyms
Protein APC; Deleted in polyposis 2.5
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Gene Name APC
Chromosomal Location 5q22.2
Family Adenomatous polyposis coli (APC) family
Function
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
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Gene ID 324
Uniprot ID
APC_HUMAN
HGNC ID
HGNC:583
Ensembl Gene ID
ENSG00000134982
KEGG ID
hsa:324
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
APC can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL3-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 6.65E-01
p-value: 8.92E-49
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between APC and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 2.14E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A-RNA immunoprecipitation sequencing revealed that METTL3 upregulates the m6A modification of Adenomatous polyposis coli protein (APC), which recruits YTHDF for APC mRNA degradation. Our findings reveal a mechanism by which the Wnt/Bete-catenin pathway is upregulated in ESCC via METTL3/YTHDF-coupled epitranscriptomal downregulation of APC.
Target Regulation Down regulation
Responsed Disease Esophageal cancer ICD-11: 2B70
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
Cell cycle hsa04110
Glycolysis / Gluconeogenesis hsa00010
Cell Process Glycolysis
In-vitro Model TE-10 Esophageal squamous cell carcinoma Homo sapiens CVCL_1760
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
KYSE-70 Esophageal squamous cell carcinoma Homo sapiens CVCL_1356
KYSE-450 Esophageal squamous cell carcinoma Homo sapiens CVCL_1353
KYSE-410 Esophageal squamous cell carcinoma Homo sapiens CVCL_1352
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
KYSE-180 Esophageal squamous cell carcinoma Homo sapiens CVCL_1349
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-140 Esophageal squamous cell carcinoma Homo sapiens CVCL_1347
HET-1A Normal Homo sapiens CVCL_3702
In-vivo Model For the subcutaneous implantation model, 1 × 106 cells were injected subcutaneously into the flank regions of female BALB/c nude mice (4-5 weeks).
Esophageal cancer [ICD-11: 2B70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A-RNA immunoprecipitation sequencing revealed that METTL3 upregulates the m6A modification of Adenomatous polyposis coli protein (APC), which recruits YTHDF for APC mRNA degradation. Our findings reveal a mechanism by which the Wnt/Bete-catenin pathway is upregulated in ESCC via METTL3/YTHDF-coupled epitranscriptomal downregulation of APC.
Responsed Disease Esophageal cancer [ICD-11: 2B70]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Wnt signaling pathway hsa04310
Cell cycle hsa04110
Glycolysis / Gluconeogenesis hsa00010
Cell Process Glycolysis
In-vitro Model TE-10 Esophageal squamous cell carcinoma Homo sapiens CVCL_1760
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
KYSE-70 Esophageal squamous cell carcinoma Homo sapiens CVCL_1356
KYSE-450 Esophageal squamous cell carcinoma Homo sapiens CVCL_1353
KYSE-410 Esophageal squamous cell carcinoma Homo sapiens CVCL_1352
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
KYSE-180 Esophageal squamous cell carcinoma Homo sapiens CVCL_1349
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
KYSE-140 Esophageal squamous cell carcinoma Homo sapiens CVCL_1347
HET-1A Normal Homo sapiens CVCL_3702
In-vivo Model For the subcutaneous implantation model, 1 × 106 cells were injected subcutaneously into the flank regions of female BALB/c nude mice (4-5 weeks).
References
Ref 1 METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding. Nat Commun. 2021 Jun 21;12(1):3803. doi: 10.1038/s41467-021-23501-5.