m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00743)
Target Name hsa-miR-30d
Synonyms
hsa-mir-30d; MIRN30D
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Gene Name hsa-miR-30d
Chromosomal Location 8q24.22
Gene ID 407033
HGNC ID
HGNC:31628
Ensembl Gene ID
ENSG00000199153
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-30d can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary MiR-30d is a novel target for YTHDC1 through m6A modification, and hsa-miR-30d represses pancreatic ductal adenocarcinoma tumorigenesis via suppressing aerobic glycolysis.
Responsed Disease Pancreatic ductal adenocarcinoma ICD-11: 2C10.0
 Disease Info 
Pathway Response Central carbon metabolism in cancer hsa05230
Glycolysis / Gluconeogenesis hsa00010
Cell Process Glycolysis
In-vitro Model SW1990 Pancreatic adenocarcinoma Homo sapiens CVCL_1723
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
HPNE (Pancreatic ductal adenocarcinoma cell line HPNE were a gift from Dr. Lingye Tao from Renji hospital)
HPAC Pancreatic adenocarcinoma Homo sapiens CVCL_3517
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0026
Capan-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0237
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
In-vivo Model To study the effect of miR-30d on liver metastasis of PDACs, 5 × 106 cells in 50 uL of PBS were injected into the spleens of nude mice (6 mice per group). Anesthetized mice were injected intraperitoneally with D-luciferin (150 mg/kg) every other week and imaged using an IVIS 100 imaging system (Xenogen, CA, USA) 10?min after the injection. The mice were sacrificed and their liver metastases were checked by standard histological examination 8-9 weeks after injection.
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary MiR-30d is a novel target for YTHDC1 through m6A modification, and hsa-miR-30d represses pancreatic ductal adenocarcinoma tumorigenesis via suppressing aerobic glycolysis.
Responsed Disease Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Pathway Response Central carbon metabolism in cancer hsa05230
Glycolysis / Gluconeogenesis hsa00010
Cell Process Glycolysis
In-vitro Model SW1990 Pancreatic adenocarcinoma Homo sapiens CVCL_1723
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
HPNE (Pancreatic ductal adenocarcinoma cell line HPNE were a gift from Dr. Lingye Tao from Renji hospital)
HPAC Pancreatic adenocarcinoma Homo sapiens CVCL_3517
CFPAC-1 Cystic fibrosis Homo sapiens CVCL_1119
Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0026
Capan-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0237
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0152
In-vivo Model To study the effect of miR-30d on liver metastasis of PDACs, 5 × 106 cells in 50 uL of PBS were injected into the spleens of nude mice (6 mice per group). Anesthetized mice were injected intraperitoneally with D-luciferin (150 mg/kg) every other week and imaged using an IVIS 100 imaging system (Xenogen, CA, USA) 10?min after the injection. The mice were sacrificed and their liver metastases were checked by standard histological examination 8-9 weeks after injection.
References
Ref 1 YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect. Cell Death Differ. 2021 Nov;28(11):3105-3124. doi: 10.1038/s41418-021-00804-0. Epub 2021 May 21.