m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00740)
Target Name Dual specificity protein phosphatase 5 (DUSP5)
Synonyms
Dual specificity protein phosphatase hVH3
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Gene Name DUSP5
Chromosomal Location 10q25.2
Family Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Function
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
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Gene ID 1847
Uniprot ID
DUS5_HUMAN
HGNC ID
HGNC:3071
Ensembl Gene ID
ENSG00000138166
KEGG ID
hsa:1847
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DUSP5 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line LNCaP cell line Homo sapiens
Treatment: shMETTL3 LNCaP cells
Control: shControl LNCaP cells
 GSE147884
Regulation
logFC: -7.11E-01
p-value: 1.15E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3-mediated m6A-modification profile in gallbladder-cancer cells and identified Dual specificity protein phosphatase 5 (DUSP5) as the downstream gene of METTL3. METTL3 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner.
Target Regulation Down regulation
Responsed Disease Gallbladder cancer ICD-11: 2C13
 Disease Info 
Cell Process Cell proliferation
Cell invasion
Cell migration
In-vitro Model NOZ Gallbladder carcinoma Homo sapiens CVCL_3079
GBC-SD Human gallbladder Homo sapiens CVCL_6903
Gallbladder cancer [ICD-11: 2C13]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3-mediated m6A-modification profile in gallbladder-cancer cells and identified Dual specificity protein phosphatase 5 (DUSP5) as the downstream gene of METTL3. METTL3 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner.
Responsed Disease Gallbladder cancer [ICD-11: 2C13]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell proliferation
Cell invasion
Cell migration
In-vitro Model NOZ Gallbladder carcinoma Homo sapiens CVCL_3079
GBC-SD Human gallbladder Homo sapiens CVCL_6903
References
Ref 1 METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression. Cancer Gene Ther. 2022 Jul;29(7):1012-1020. doi: 10.1038/s41417-021-00406-5. Epub 2021 Nov 19.