m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0146)
| Name |
Gallbladder cancer
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|---|---|---|---|---|---|
| ICD |
ICD-11: 2C13
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Full List of Target Gene(s) of This m6A-centered Disease Response
Dual specificity protein phosphatase 5 (DUSP5)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | METTL3-mediated m6A-modification profile in gallbladder-cancer cells and identified Dual specificity protein phosphatase 5 (DUSP5) as the downstream gene of METTL3. METTL3 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner. | |||
| Responsed Disease | Gallbladder cancer [ICD-11: 2C13] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Cell Process | Cell proliferation | |||
| Cell invasion | ||||
| Cell migration | ||||
| In-vitro Model | NOZ | Gallbladder carcinoma | Homo sapiens | CVCL_3079 |
| GBC-SD | Human gallbladder | Homo sapiens | CVCL_6903 | |