m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00725)
Target Name Titin
Synonyms
Connectin; Rhabdomyosarcoma antigen MU-RMS-40.14
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Gene Name Titin
Chromosomal Location 2q31.2
Family Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Function
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
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Gene ID 7273
Uniprot ID
TITIN_HUMAN
HGNC ID
HGNC:12403
Ensembl Gene ID
ENSG00000155657
KEGG ID
hsa:7273
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Titin can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDC1
Cell Line MOLM-13 cell line Homo sapiens
Treatment: shYTHDC1 MOLM13 cells
Control: shControl MOLM13 cells
 GSE168565
Regulation
logFC: 1.29E+00
p-value: 9.48E-11
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary This study suggests that YTHDC1 plays crucial role in regulating the normal contractile function and the development of dilated cardiomyopathy.
Responsed Disease Dilated cardiomyopathy ICD-11: BC43.0
 Disease Info 
In-vitro Model Neonatal rat ventricular cardiomyocytes (Primary myocyte cells)
Cardiomyopathy [ICD-11: BC43]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary This study suggests that YTHDC1 plays crucial role in regulating the normal contractile function and the development of dilated cardiomyopathy.
Responsed Disease Dilated cardiomyopathy [ICD-11: BC43.0]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
In-vitro Model Neonatal rat ventricular cardiomyocytes (Primary myocyte cells)
References
Ref 1 Depletion of m(6) A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin. J Cell Mol Med. 2021 Dec;25(23):10879-10891. doi: 10.1111/jcmm.16955. Epub 2021 Oct 30.