m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00695)
Target Name PHD finger protein 10 (PHF10)
Synonyms
BRG1-associated factor 45a; BAF45a; XAP135
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Gene Name PHF10
Chromosomal Location 6q27
Family SAYP family
Function
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
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Gene ID 55274
Uniprot ID
PHF10_HUMAN
HGNC ID
HGNC:18250
Ensembl Gene ID
ENSG00000130024
KEGG ID
hsa:55274
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PHF10 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Zinc finger CCCH domain-containing protein 13 (ZC3H13) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ZC3H13
Cell Line mouse embryonic stem cells Mus musculus
Treatment: ZC3H13-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: -1.07E+00
p-value: 1.29E-67
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary DNA damage repair is a major barrier for chemotherapy efficacy of pancreatic cancer, it's the first time that PHD finger protein 10 (PHF10) was found and involved in the DNA damage response. ZC3H13 knockdown downregulated the m6A methylation of PHF10 and decreased PHF10 translation in a YTHDF1-dependent manner.
Target Regulation Down regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Pathway Response Homologous recombination hsa03440
Cell Process Homologous recombination
DNA double strand breaks
In-vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
hTERT-HPNE Normal Homo sapiens CVCL_C466
DR-GFP-U2OS (DR-GFP-U2OS cells used for HR assay were generously provided by Huang Lab (Zhejiang University))
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary DNA damage repair is a major barrier for chemotherapy efficacy of pancreatic cancer, it's the first time that PHD finger protein 10 (PHF10) was found and involved in the DNA damage response. ZC3H13 knockdown downregulated the m6A methylation of PHF10 and decreased PHF10 translation in a YTHDF1-dependent manner.
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator Zinc finger CCCH domain-containing protein 13 (ZC3H13) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Homologous recombination hsa03440
Cell Process Homologous recombination
DNA double strand breaks
In-vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
hTERT-HPNE Normal Homo sapiens CVCL_C466
DR-GFP-U2OS (DR-GFP-U2OS cells used for HR assay were generously provided by Huang Lab (Zhejiang University))
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0186
References
Ref 1 ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer. Cancer Lett. 2022 Apr 1;530:16-28. doi: 10.1016/j.canlet.2022.01.013. Epub 2022 Jan 14.