m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00686)
Target Name Tyrosine-protein kinase receptor Tie-1 (TIE1)
Gene Name TIE1
Chromosomal Location 1p34.2
Family Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
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Gene ID 7075
Uniprot ID
TIE1_HUMAN
HGNC ID
HGNC:11809
Ensembl Gene ID
ENSG00000066056
KEGG ID
hsa:7075
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TIE1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line HepG2 cell line Homo sapiens
Treatment: shMETTL14 HepG2 cells
Control: shCtrl HepG2 cells
 GSE121949
Regulation
logFC: -1.32E+00
p-value: 5.08E-05
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The overexpression of miR-4729 in vascular endothelial cells decreased the global mRNA methylation and TIE1 mRNA 3'UTR-specific site methylation by silencing METTL14 expression, reducing Tyrosine-protein kinase receptor Tie-1 (TIE1) mRNA stability, down-regulating the TIE1/VEGFA signal molecular loop expression, and weakening angiogenesis ability. MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14.
Target Regulation Up regulation
Responsed Disease Haemorrhoids ICD-11: DB60
 Disease Info 
Pathway Response VEGF signaling pathway hsa04370
Cell Process Cell proliferation
In-vitro Model HUVEC-C Normal Homo sapiens CVCL_2959
Haemorrhoids [ICD-11: DB60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The overexpression of miR-4729 in vascular endothelial cells decreased the global mRNA methylation and TIE1 mRNA 3'UTR-specific site methylation by silencing METTL14 expression, reducing Tyrosine-protein kinase receptor Tie-1 (TIE1) mRNA stability, down-regulating the TIE1/VEGFA signal molecular loop expression, and weakening angiogenesis ability. MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14.
Responsed Disease Haemorrhoids [ICD-11: DB60]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response VEGF signaling pathway hsa04370
Cell Process Cell proliferation
In-vitro Model HUVEC-C Normal Homo sapiens CVCL_2959
References
Ref 1 MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14. Ann Transl Med. 2021 Feb;9(3):232. doi: 10.21037/atm-20-3399.