m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00681)
Target Name DNA damage-binding protein 2 (DDB2)
Synonyms
DDB p48 subunit; DDBb; Damage-specific DNA-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2
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Gene Name DDB2
Chromosomal Location 11p11.2
Family WD repeat DDB2/WDR76 family
Function
Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR; Inhibits UV-damaged DNA repair; Inhibits UV-damaged DNA repair.
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Gene ID 1643
Uniprot ID
DDB2_HUMAN
HGNC ID
HGNC:2718
Ensembl Gene ID
ENSG00000134574
KEGG ID
hsa:1643
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
DDB2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line MDA-MB-231 Homo sapiens
Treatment: siMETTL14 MDA-MB-231 cells
Control: MDA-MB-231 cells
 GSE81164
Regulation
logFC: -7.35E-01
p-value: 7.54E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL14 knockdown decreases GGR and DNA damage-binding protein 2 (DDB2) abundance. Conversely, overexpression of wild-type METTL14 but not its enzymatically inactive mutant increases GGR and DDB2 abundance. METTL14 is a target for selective autophagy and acts as a critical epitranscriptomic mechanism to regulate GGR and suppress UVB-induced skin tumorigenesis.
Target Regulation Up regulation
Responsed Disease Skin tumour ICD-11: 2F92
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process Genome repair
Cell autophagy
In-vitro Model NHEK (Normal human epithelial keratinocytes)
MEF (Mouse embryonic fibroblasts)
HaCaT Normal Homo sapiens CVCL_0038
A-431 Skin squamous cell carcinoma Homo sapiens CVCL_0037
Skin tumour [ICD-11: 2F92]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL14 knockdown decreases GGR and DNA damage-binding protein 2 (DDB2) abundance. Conversely, overexpression of wild-type METTL14 but not its enzymatically inactive mutant increases GGR and DDB2 abundance. METTL14 is a target for selective autophagy and acts as a critical epitranscriptomic mechanism to regulate GGR and suppress UVB-induced skin tumorigenesis.
Responsed Disease Skin tumour [ICD-11: 2F92]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process Genome repair
Cell autophagy
In-vitro Model NHEK (Normal human epithelial keratinocytes)
MEF (Mouse embryonic fibroblasts)
HaCaT Normal Homo sapiens CVCL_0038
A-431 Skin squamous cell carcinoma Homo sapiens CVCL_0037
References
Ref 1 METTL14 facilitates global genome repair and suppresses skin tumorigenesis. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2025948118. doi: 10.1073/pnas.2025948118.