m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00672)
Target Name hsa-miR-320a-3p
Gene Name hsa-miR-320a-3p
miRBase ID
MIMAT0000510
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-320a-3p can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 promotes silica-induced lung fibrosis via the hsa-miR-320a-3p/FOXM1 axis or targeting FOXM1 directly.
Target Regulation Down regulation
Responsed Disease Pulmonary Fibrosis ICD-11: CB03.4
 Disease Info 
In-vitro Model NIH 3T3 Normal Mus musculus CVCL_0594
MRC-5 Normal Homo sapiens CVCL_0440
In-vivo Model For the mouse model of miR-320a-3p overexpression, a total of 24 male C57BL/6 mice were divided randomly into four groups (n = 6 in each group): saline, silica, silica plus AAV9-miR-NC, and silica plus AAV9-miR-320a-3p. The mice in the silica plus AAV9-miR-NC/AAV9-miR-320a-3p groups were anesthetized using the same method, then administered intratracheally 50 uL AAV9-miR-NC/AAV9-miR-320a-3p per mouse at a titer of 8 × 1012 v. g./ml. Three weeks later, these mice were treated in the same way using anesthesia, saline, and silica as mentioned above. Subsequently, after 4 weeks, the mice were sacrificed, and the lungs were isolated and frozen at -80 ℃ for further study.
Idiopathic interstitial pneumonitis [ICD-11: CB03]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 promotes silica-induced lung fibrosis via the hsa-miR-320a-3p/FOXM1 axis or targeting FOXM1 directly.
Responsed Disease Pulmonary Fibrosis [ICD-11: CB03.4]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model NIH 3T3 Normal Mus musculus CVCL_0594
MRC-5 Normal Homo sapiens CVCL_0440
In-vivo Model For the mouse model of miR-320a-3p overexpression, a total of 24 male C57BL/6 mice were divided randomly into four groups (n = 6 in each group): saline, silica, silica plus AAV9-miR-NC, and silica plus AAV9-miR-320a-3p. The mice in the silica plus AAV9-miR-NC/AAV9-miR-320a-3p groups were anesthetized using the same method, then administered intratracheally 50 uL AAV9-miR-NC/AAV9-miR-320a-3p per mouse at a titer of 8 × 1012 v. g./ml. Three weeks later, these mice were treated in the same way using anesthesia, saline, and silica as mentioned above. Subsequently, after 4 weeks, the mice were sacrificed, and the lungs were isolated and frozen at -80 ℃ for further study.
References
Ref 1 ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1. Cell Mol Biol Lett. 2022 Mar 12;27(1):26. doi: 10.1186/s11658-022-00329-5.