m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00633)
Target Name Protein RCC2 (RCC2)
Synonyms
RCC1-like protein TD-60; Telophase disk protein of 60 kDa
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Gene Name RCC2
Chromosomal Location 1p36.13
Function
Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis . Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions. Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro).
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Gene ID 55920
Uniprot ID
RCC2_HUMAN
HGNC ID
HGNC:30297
Ensembl Gene ID
ENSG00000179051; ENSG00000281540
KEGG ID
hsa:55920
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
RCC2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between RCC2 and the regulator
Cell Line HEK293T Homo sapiens
Regulation logFC: 1.30E+00 GSE90639
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary IGF2BP3 is required for maintaining AML cell survival in an m6A-dependent manner, and knockdown of IGF2BP3 dramatically suppresses the apoptosis, reduces the proliferation, and impairs the leukemic capacity of AML cells in vitro and in vivo.IGF2BP3 interacts with Protein RCC2 (RCC2) mRNA and stabilizes the expression of m6A-modified RNA.
Target Regulation Up regulation
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Cell Process Cell apoptosis
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
SUP-B15 B-lymphoblastic leukemia Homo sapiens CVCL_0103
KG-1 Adult acute myeloid leukemia Homo sapiens CVCL_0374
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
HL-60 Adult acute myeloid leukemia Homo sapiens CVCL_0002
Acute myeloid leukaemia [ICD-11: 2A60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary IGF2BP3 is required for maintaining AML cell survival in an m6A-dependent manner, and knockdown of IGF2BP3 dramatically suppresses the apoptosis, reduces the proliferation, and impairs the leukemic capacity of AML cells in vitro and in vivo.IGF2BP3 interacts with Protein RCC2 (RCC2) mRNA and stabilizes the expression of m6A-modified RNA.
Responsed Disease Acute myeloid leukaemia [ICD-11: 2A60]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell apoptosis
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
SUP-B15 B-lymphoblastic leukemia Homo sapiens CVCL_0103
KG-1 Adult acute myeloid leukemia Homo sapiens CVCL_0374
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
HL-60 Adult acute myeloid leukemia Homo sapiens CVCL_0002
References
Ref 1 The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability. Exp Mol Med. 2022 Feb;54(2):194-205. doi: 10.1038/s12276-022-00735-x. Epub 2022 Feb 25.