m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00608)
Target Name Pigment epithelium-derived factor (PEDF)
Synonyms
PEDF; Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1
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Gene Name PEDF
Chromosomal Location 17p13.3
Family Serpin family
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
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Gene ID 5176
Uniprot ID
PEDF_HUMAN
HGNC ID
HGNC:8824
Ensembl Gene ID
ENSG00000132386
KEGG ID
hsa:5176
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PEDF can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -9.30E-01
p-value: 1.13E-16
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between PEDF and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 8.75E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Overexpressed Pigment epithelium-derived factor (PEDF) abrogates the inhibition of cell proliferation in DLBCL cells that is caused by METTL3 silence.
Target Regulation Up regulation
Responsed Disease Diffuse large B-cell lymphomas ICD-11: 2A81
 Disease Info 
In-vitro Model U-2932 Diffuse large B-cell lymphoma Homo sapiens CVCL_1896
SU-DHL-4 Diffuse large B-cell lymphoma Homo sapiens CVCL_0539
OCI-Ly10 Diffuse large B-cell lymphoma Homo sapiens CVCL_8795
HBL-1 [Human diffuse large B-cell lymphoma] Diffuse large B-cell lymphoma Homo sapiens CVCL_4213
GM12878 Human B lymphocytes Homo sapiens CVCL_7526
Farage Diffuse large B-cell lymphoma Homo sapiens CVCL_3302
Diffuse large B-cell lymphomas [ICD-11: 2A81]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Overexpressed Pigment epithelium-derived factor (PEDF) abrogates the inhibition of cell proliferation in DLBCL cells that is caused by METTL3 silence.
Responsed Disease Diffuse large B-cell lymphomas [ICD-11: 2A81]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model U-2932 Diffuse large B-cell lymphoma Homo sapiens CVCL_1896
SU-DHL-4 Diffuse large B-cell lymphoma Homo sapiens CVCL_0539
OCI-Ly10 Diffuse large B-cell lymphoma Homo sapiens CVCL_8795
HBL-1 [Human diffuse large B-cell lymphoma] Diffuse large B-cell lymphoma Homo sapiens CVCL_4213
GM12878 Human B lymphocytes Homo sapiens CVCL_7526
Farage Diffuse large B-cell lymphoma Homo sapiens CVCL_3302
References
Ref 1 The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF. Front Genet. 2020 Aug 27;11:955. doi: 10.3389/fgene.2020.00955. eCollection 2020.