m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0177)
Name
Diffuse large B-cell lymphomas
ICD
ICD-11: 2A81
Full List of Target Gene(s) of This m6A-centered Disease Response
Pigment epithelium-derived factor (PEDF)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Overexpressed Pigment epithelium-derived factor (PEDF) abrogates the inhibition of cell proliferation in DLBCL cells that is caused by METTL3 silence.
Responsed Disease Diffuse large B-cell lymphomas [ICD-11: 2A81]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model U-2932 Diffuse large B-cell lymphoma Homo sapiens CVCL_1896
SU-DHL-4 Diffuse large B-cell lymphoma Homo sapiens CVCL_0539
OCI-Ly10 Diffuse large B-cell lymphoma Homo sapiens CVCL_8795
HBL-1 [Human diffuse large B-cell lymphoma] Diffuse large B-cell lymphoma Homo sapiens CVCL_4213
GM12878 Human B lymphocytes Homo sapiens CVCL_7526
Farage Diffuse large B-cell lymphoma Homo sapiens CVCL_3302
References
Ref 1 The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF. Front Genet. 2020 Aug 27;11:955. doi: 10.3389/fgene.2020.00955. eCollection 2020.