m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00607)
Target Name Transcription factor 7-like 2 (TCF7L2)
Synonyms
HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4
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Gene Name TCF7L2
Chromosomal Location 10q25.2-q25.3
Family TCF/LEF family
Function
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
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Gene ID 6934
Uniprot ID
TF7L2_HUMAN
HGNC ID
HGNC:11641
Ensembl Gene ID
ENSG00000148737
KEGG ID
hsa:6934
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TCF7L2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by HNRNPA2B1
Cell Line HeLa cell line Homo sapiens
Treatment: HNRNPA2B1 knockdown HeLa cells
Control: HeLa cells
 GSE70061
Regulation
logFC: 2.87E+00
p-value: 4.26E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of Transcription factor 7-like 2 (TCF7L2) mRNA stability. These findings identified MIR100HG as a potent EMT inducer in CRC that contribute to cetuximab resistance and metastasis by activation of a MIR100HG/hnRNPA2B1/TCF7L2 feedback loop.
Target Regulation Up regulation
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Responsed Drug Cetuximab Approved
 Drug Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Epithelial-mesenchymal transition
In-vitro Model VACO 9P Rectal adenocarcinoma Homo sapiens CVCL_5413
T84 Colon adenocarcinoma Homo sapiens CVCL_0555
SW948 Colon adenocarcinoma Homo sapiens CVCL_0632
SW837 Rectal adenocarcinoma Homo sapiens CVCL_1729
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW48 Colon adenocarcinoma Homo sapiens CVCL_1724
SW403 Colon adenocarcinoma Homo sapiens CVCL_0545
SW1116 Colon adenocarcinoma Homo sapiens CVCL_0544
SK-CO-1 Colon adenocarcinoma Homo sapiens CVCL_0626
RKO Colon carcinoma Homo sapiens CVCL_0504
NCI-H716 Cecum adenocarcinoma Homo sapiens CVCL_1581
NCI-H508 Cecum adenocarcinoma Homo sapiens CVCL_1564
LS174T Colon adenocarcinoma Homo sapiens CVCL_1384
LS123 Colon adenocarcinoma Homo sapiens CVCL_1383
LoVo Colon adenocarcinoma Homo sapiens CVCL_0399
LIM2405 Cecum adenocarcinoma Homo sapiens CVCL_4437
LIM1215 Colon adenocarcinoma Homo sapiens CVCL_2574
HuTu 80 Duodenal adenocarcinoma Homo sapiens CVCL_1301
HT29 Colon cancer Mus musculus CVCL_A8EZ
HCT 8 Colon adenocarcinoma Homo sapiens CVCL_2478
HCT 15 Colon adenocarcinoma Homo sapiens CVCL_0292
HCT 116 Colon carcinoma Homo sapiens CVCL_0291
GEO Colon carcinoma Homo sapiens CVCL_0271
DLD-1 Colon adenocarcinoma Homo sapiens CVCL_0248
DiFi Colorectal carcinoma Homo sapiens CVCL_6895
COLO 320DM Colon adenocarcinoma Homo sapiens CVCL_0219
COLO 205 Colon adenocarcinoma Homo sapiens CVCL_0218
Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
In-vivo Model Established subcutaneous xenografts in athymic nude mice with MIR100HGKOE4 CC-CR cells transduced with a luciferase-expressing lentiviral vector and then treated the mice with cetuximab.
Colorectal cancer [ICD-11: 2B91]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of Transcription factor 7-like 2 (TCF7L2) mRNA stability. These findings identified MIR100HG as a potent EMT inducer in CRC that contribute to cetuximab resistance and metastasis by activation of a MIR100HG/hnRNPA2B1/TCF7L2 feedback loop.
Responsed Disease Colorectal cancer [ICD-11: 2B91]
Target Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) READER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Cetuximab Approved
 Drug Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Epithelial-mesenchymal transition
In-vitro Model VACO 9P Rectal adenocarcinoma Homo sapiens CVCL_5413
T84 Colon adenocarcinoma Homo sapiens CVCL_0555
SW948 Colon adenocarcinoma Homo sapiens CVCL_0632
SW837 Rectal adenocarcinoma Homo sapiens CVCL_1729
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW48 Colon adenocarcinoma Homo sapiens CVCL_1724
SW403 Colon adenocarcinoma Homo sapiens CVCL_0545
SW1116 Colon adenocarcinoma Homo sapiens CVCL_0544
SK-CO-1 Colon adenocarcinoma Homo sapiens CVCL_0626
RKO Colon carcinoma Homo sapiens CVCL_0504
NCI-H716 Cecum adenocarcinoma Homo sapiens CVCL_1581
NCI-H508 Cecum adenocarcinoma Homo sapiens CVCL_1564
LS174T Colon adenocarcinoma Homo sapiens CVCL_1384
LS123 Colon adenocarcinoma Homo sapiens CVCL_1383
LoVo Colon adenocarcinoma Homo sapiens CVCL_0399
LIM2405 Cecum adenocarcinoma Homo sapiens CVCL_4437
LIM1215 Colon adenocarcinoma Homo sapiens CVCL_2574
HuTu 80 Duodenal adenocarcinoma Homo sapiens CVCL_1301
HT29 Colon cancer Mus musculus CVCL_A8EZ
HCT 8 Colon adenocarcinoma Homo sapiens CVCL_2478
HCT 15 Colon adenocarcinoma Homo sapiens CVCL_0292
HCT 116 Colon carcinoma Homo sapiens CVCL_0291
GEO Colon carcinoma Homo sapiens CVCL_0271
DLD-1 Colon adenocarcinoma Homo sapiens CVCL_0248
DiFi Colorectal carcinoma Homo sapiens CVCL_6895
COLO 320DM Colon adenocarcinoma Homo sapiens CVCL_0219
COLO 205 Colon adenocarcinoma Homo sapiens CVCL_0218
Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
In-vivo Model Established subcutaneous xenografts in athymic nude mice with MIR100HGKOE4 CC-CR cells transduced with a luciferase-expressing lentiviral vector and then treated the mice with cetuximab.
Cetuximab [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of Transcription factor 7-like 2 (TCF7L2) mRNA stability. These findings identified MIR100HG as a potent EMT inducer in CRC that contribute to cetuximab resistance and metastasis by activation of a MIR100HG/hnRNPA2B1/TCF7L2 feedback loop.
Target Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) READER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Epithelial-mesenchymal transition
In-vitro Model VACO 9P Rectal adenocarcinoma Homo sapiens CVCL_5413
T84 Colon adenocarcinoma Homo sapiens CVCL_0555
SW948 Colon adenocarcinoma Homo sapiens CVCL_0632
SW837 Rectal adenocarcinoma Homo sapiens CVCL_1729
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW48 Colon adenocarcinoma Homo sapiens CVCL_1724
SW403 Colon adenocarcinoma Homo sapiens CVCL_0545
SW1116 Colon adenocarcinoma Homo sapiens CVCL_0544
SK-CO-1 Colon adenocarcinoma Homo sapiens CVCL_0626
RKO Colon carcinoma Homo sapiens CVCL_0504
NCI-H716 Cecum adenocarcinoma Homo sapiens CVCL_1581
NCI-H508 Cecum adenocarcinoma Homo sapiens CVCL_1564
LS174T Colon adenocarcinoma Homo sapiens CVCL_1384
LS123 Colon adenocarcinoma Homo sapiens CVCL_1383
LoVo Colon adenocarcinoma Homo sapiens CVCL_0399
LIM2405 Cecum adenocarcinoma Homo sapiens CVCL_4437
LIM1215 Colon adenocarcinoma Homo sapiens CVCL_2574
HuTu 80 Duodenal adenocarcinoma Homo sapiens CVCL_1301
HT29 Colon cancer Mus musculus CVCL_A8EZ
HCT 8 Colon adenocarcinoma Homo sapiens CVCL_2478
HCT 15 Colon adenocarcinoma Homo sapiens CVCL_0292
HCT 116 Colon carcinoma Homo sapiens CVCL_0291
GEO Colon carcinoma Homo sapiens CVCL_0271
DLD-1 Colon adenocarcinoma Homo sapiens CVCL_0248
DiFi Colorectal carcinoma Homo sapiens CVCL_6895
COLO 320DM Colon adenocarcinoma Homo sapiens CVCL_0219
COLO 205 Colon adenocarcinoma Homo sapiens CVCL_0218
Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
In-vivo Model Established subcutaneous xenografts in athymic nude mice with MIR100HGKOE4 CC-CR cells transduced with a luciferase-expressing lentiviral vector and then treated the mice with cetuximab.
References
Ref 1 Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression. Mol Cancer. 2022 Mar 12;21(1):74. doi: 10.1186/s12943-022-01555-3.