m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00603)
Target Name Homeobox protein Hox-A1 (HOXA1)
Synonyms
Homeobox protein Hox-1F
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Gene Name HOXA1
Chromosomal Location 7p15.2
Family Antp homeobox family, Labial subfamily
Function
Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior. Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).
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Gene ID 3198
Uniprot ID
HXA1_HUMAN
HGNC ID
HGNC:5099
KEGG ID
hsa:3198
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HOXA1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Protein virilizer homolog (VIRMA) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A methyltransferase KIAA1429 was highly expressed in gefitinib-resistant NSCLC cells (PC9-GR), tissues, and closely related to unfavorable survival. KIAA1429 plays essential oncogenic roles in NSCLC gefitinib resistance, which provided a feasible therapeutic target for NSCLC.
Target Regulation Up regulation
Responsed Disease Non-small-cell lung carcinoma ICD-11: 2C25.Y
 Disease Info 
Responsed Drug Gefitinib Approved
 Drug Info 
In-vitro Model Gefitinib-resistant cell line PC9GR (Gefitinib-resistant PC9 cell line)
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
NHBE (Normal bronchial epithelial cells)
In-vivo Model PC9-GR cells stably infected with KIAA1429-targeting shRNA and control were suspended in 100 uL of PBS with Matrigel matrix (BD Biosciences). Then, cells were injected into one of the flanks of BALB/c nude mice.
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A methyltransferase KIAA1429 was highly expressed in gefitinib-resistant NSCLC cells (PC9-GR), tissues, and closely related to unfavorable survival. KIAA1429 plays essential oncogenic roles in NSCLC gefitinib resistance, which provided a feasible therapeutic target for NSCLC.
Responsed Disease Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Gefitinib Approved
 Drug Info 
In-vitro Model Gefitinib-resistant cell line PC9GR (Gefitinib-resistant PC9 cell line)
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
NHBE (Normal bronchial epithelial cells)
In-vivo Model PC9-GR cells stably infected with KIAA1429-targeting shRNA and control were suspended in 100 uL of PBS with Matrigel matrix (BD Biosciences). Then, cells were injected into one of the flanks of BALB/c nude mice.
Gefitinib [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary m6A methyltransferase KIAA1429 was highly expressed in gefitinib-resistant NSCLC cells (PC9-GR), tissues, and closely related to unfavorable survival. KIAA1429 plays essential oncogenic roles in NSCLC gefitinib resistance, which provided a feasible therapeutic target for NSCLC.
Target Regulator Protein virilizer homolog (VIRMA) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Non-small-cell lung carcinoma ICD-11: 2C25.Y
 Disease Info 
In-vitro Model Gefitinib-resistant cell line PC9GR (Gefitinib-resistant PC9 cell line)
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
NHBE (Normal bronchial epithelial cells)
In-vivo Model PC9-GR cells stably infected with KIAA1429-targeting shRNA and control were suspended in 100 uL of PBS with Matrigel matrix (BD Biosciences). Then, cells were injected into one of the flanks of BALB/c nude mice.
References
Ref 1 N(6)-methyladenosine (m(6)A) methyltransferase KIAA1429 accelerates the gefitinib resistance of non-small-cell lung cancer. Cell Death Discov. 2021 May 17;7(1):108. doi: 10.1038/s41420-021-00488-y.