m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00595)
Target Name Tastin (TROAP)
Synonyms
Trophinin-assisting protein; Trophinin-associated protein
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Gene Name TROAP
Chromosomal Location 12q13.12
Function
Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
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Gene ID 10024
Uniprot ID
TROAP_HUMAN
HGNC ID
HGNC:12327
Ensembl Gene ID
ENSG00000135451
KEGG ID
hsa:10024
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TROAP can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line IL7H6 cell line Mus musculus
Treatment: METTL14 knockout IL7H6 cells
Control: Wild type IL7H6 cells
 GSE151071
Regulation
logFC: -1.07E+00
p-value: 3.99E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL14 overexpression decreased ovarian cancer proliferation by inhibition of Tastin (TROAP) expression via an m6A RNA methylation-dependent mechanism.
Target Regulation Down regulation
Responsed Disease Ovarian cancer ICD-11: 2C73
 Disease Info 
In-vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens CVCL_0532
A2780 Ovarian endometrioid adenocarcinoma Homo sapiens CVCL_0134
In-vivo Model KOV-3 cells (1 ×106) stable transfected with METTL14 or control lentivirus, were injected subcutaneously into the right flank of BALB/c nude mice.
Ovarian cancer [ICD-11: 2C73]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL14 overexpression decreased ovarian cancer proliferation by inhibition of Tastin (TROAP) expression via an m6A RNA methylation-dependent mechanism.
Responsed Disease Ovarian cancer [ICD-11: 2C73]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens CVCL_0532
A2780 Ovarian endometrioid adenocarcinoma Homo sapiens CVCL_0134
In-vivo Model KOV-3 cells (1 ×106) stable transfected with METTL14 or control lentivirus, were injected subcutaneously into the right flank of BALB/c nude mice.
References
Ref 1 Downregulation of Methyltransferase-Like 14 Promotes Ovarian Cancer Cell Proliferation Through Stabilizing TROAP mRNA. Front Oncol. 2022 Feb 18;12:824258. doi: 10.3389/fonc.2022.824258. eCollection 2022.