m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00583)
Target Name F-box/LRR-repeat protein 5 (FBXL5)
Synonyms
F-box and leucine-rich repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like protein
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Gene Name FBXL5
Chromosomal Location 4p15.32
Function
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
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Gene ID 26234
Uniprot ID
FBXL5_HUMAN
HGNC ID
HGNC:13602
Ensembl Gene ID
ENSG00000118564
KEGG ID
hsa:26234
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
FBXL5 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5
Cell Line human pluripotent stem cells Homo sapiens
Treatment: hILO ALKBH5knockout cells
Control: hILO wild type cells
 GSE163945
Regulation
logFC: -8.45E-01
p-value: 2.55E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 overexpression incurred a significant reduction in iron-regulatory protein IRP2 and the modulator of epithelial-mesenchymal transition (EMT) SNAI1. Owing to F-box/LRR-repeat protein 5 (FBXL5)-mediated degradation, ALKBH5 overexpression incurred a significant reduction in iron-regulatory protein IRP2 and the modulator of epithelial-mesenchymal transition (EMT) SNAI1. ALKBH5 in protecting against PDAC through modulating regulators of iron metabolism and underscore the multifaceted role of m6A in pancreatic cancer.
Target Regulation Up regulation
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Pathway Response Adherens junction hsa04520
Cell Process Epithelial-mesenchymal transition
In-vitro Model MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 overexpression incurred a significant reduction in iron-regulatory protein IRP2 and the modulator of epithelial-mesenchymal transition (EMT) SNAI1. Owing to F-box/LRR-repeat protein 5 (FBXL5)-mediated degradation, ALKBH5 overexpression incurred a significant reduction in iron-regulatory protein IRP2 and the modulator of epithelial-mesenchymal transition (EMT) SNAI1. ALKBH5 in protecting against PDAC through modulating regulators of iron metabolism and underscore the multifaceted role of m6A in pancreatic cancer.
Responsed Disease Pancreatic cancer [ICD-11: 2C10]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Adherens junction hsa04520
Cell Process Epithelial-mesenchymal transition
In-vitro Model MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0428
References
Ref 1 RNA m(6)A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism. Front Cell Dev Biol. 2021 Oct 18;9:724282. doi: 10.3389/fcell.2021.724282. eCollection 2021.