m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00556)
Target Name Bcl-2-modifying factor (BMF)
Gene Name BMF
Chromosomal Location 15q15.1
Family Bcl-2 family
Function
May play a role in apoptosis. Isoform 1 seems to be the main initiator.
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Gene ID 90427
Uniprot ID
BMF_HUMAN
HGNC ID
HGNC:24132
Ensembl Gene ID
ENSG00000104081
KEGG ID
hsa:90427
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
BMF can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line Human umbilical cord blood CD34+ cells Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells
Control: Wild type UCB CD34+ cells
 GSE107956
Regulation
logFC: 1.29E+00
p-value: 2.46E-03
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between BMF and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 2.27E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary FBW7 suppresses tumor growth and progression via antagonizing YTHDF2-mediated Bcl-2-modifying factor (BMF) mRNA decay in ovarian cancer.
Target Regulation Down regulation
Responsed Disease Ovarian cancer ICD-11: 2C73
 Disease Info 
Cell Process RNA stability
Cell apoptosis
In-vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens CVCL_0532
OVCAR-8 High grade ovarian serous adenocarcinoma Homo sapiens CVCL_1629
OVCA429 Ovarian cystadenocarcinoma Homo sapiens CVCL_3936
OVCA420 Ovarian serous adenocarcinoma Homo sapiens CVCL_3935
In-vivo Model 5 × 106 cells were suspended in 100 uL PBS and then were inoculated subcutaneously.
Ovarian cancer [ICD-11: 2C73]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary FBW7 suppresses tumor growth and progression via antagonizing YTHDF2-mediated Bcl-2-modifying factor (BMF) mRNA decay in ovarian cancer.
Responsed Disease Ovarian cancer [ICD-11: 2C73]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Cell Process RNA stability
Cell apoptosis
In-vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens CVCL_0532
OVCAR-8 High grade ovarian serous adenocarcinoma Homo sapiens CVCL_1629
OVCA429 Ovarian cystadenocarcinoma Homo sapiens CVCL_3936
OVCA420 Ovarian serous adenocarcinoma Homo sapiens CVCL_3935
In-vivo Model 5 × 106 cells were suspended in 100 uL PBS and then were inoculated subcutaneously.
References
Ref 1 FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2. Mol Cancer. 2021 Mar 3;20(1):45. doi: 10.1186/s12943-021-01340-8.