m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00549)
Target Name P2X purinoceptor 6 (P2RX6)
Synonyms
P2X6; ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1
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Gene Name P2RX6
Chromosomal Location 22q11.21
Family P2X receptor family
Function
Receptor for ATP that acts as a ligand-gated ion channel.
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Gene ID 9127
Uniprot ID
P2RX6_HUMAN
HGNC ID
HGNC:8538
Ensembl Gene ID
ENSG00000099957
KEGG ID
hsa:9127
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
P2RX6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In RCC, METTL14 implicated m6A modification in RCC and down-regulated P2X purinoceptor 6 (P2RX6) protein translation.
Target Regulation Down regulation
Responsed Disease Renal cell carcinoma ICD-11: 2C90
 Disease Info 
Cell Process Cell invasion and metastasis
In-vitro Model SW839 Clear cell renal cell carcinoma Homo sapiens CVCL_3604
SN12C-PM6 Renal cell carcinoma Homo sapiens CVCL_9549
OS-RC-2 Clear cell renal cell carcinoma Homo sapiens CVCL_1626
HEK293 Normal Homo sapiens CVCL_0045
786-O Renal cell carcinoma Homo sapiens CVCL_1051
In-vivo Model For the in vivo metastasis assays, luciferase labeled OS-RC-2 cells stably expressing OE-P2RX6 or pWPI-vector were injected into the tail vein of 5 weeks old BALB/c nude mice (Sipper-BK laboratory animal Company, Shanghai, China).
Renal cell carcinoma [ICD-11: 2C90]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary In RCC, METTL14 implicated m6A modification in RCC and down-regulated P2X purinoceptor 6 (P2RX6) protein translation.
Responsed Disease Renal cell carcinoma [ICD-11: 2C90]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell invasion and metastasis
In-vitro Model SW839 Clear cell renal cell carcinoma Homo sapiens CVCL_3604
SN12C-PM6 Renal cell carcinoma Homo sapiens CVCL_9549
OS-RC-2 Clear cell renal cell carcinoma Homo sapiens CVCL_1626
HEK293 Normal Homo sapiens CVCL_0045
786-O Renal cell carcinoma Homo sapiens CVCL_1051
In-vivo Model For the in vivo metastasis assays, luciferase labeled OS-RC-2 cells stably expressing OE-P2RX6 or pWPI-vector were injected into the tail vein of 5 weeks old BALB/c nude mice (Sipper-BK laboratory animal Company, Shanghai, China).
References
Ref 1 The m(6)A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca(2+) influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. J Exp Clin Cancer Res. 2019 Jun 3;38(1):233. doi: 10.1186/s13046-019-1223-y.