m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00544)
Target Name Engulfment and cell motility protein 1 (ELMO1)
Synonyms
Protein ced-12 homolog
    Click to Show/Hide
Gene Name ELMO1
Chromosomal Location 7p14.2-p14.1
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
    Click to Show/Hide
Gene ID 9844
Uniprot ID
ELMO1_HUMAN
HGNC ID
HGNC:16286
Ensembl Gene ID
ENSG00000155849
KEGG ID
hsa:9844
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ELMO1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line HepG2 cell line Homo sapiens
Treatment: shMETTL14 HepG2 cells
Control: shCtrl HepG2 cells
 GSE121949
Regulation
logFC: 2.58E+00
p-value: 2.13E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary TNF-alpha leads to increased expression of ELMO1 in AS-MSC, which is mediated by a METTL14 dependent m6A modification in Engulfment and cell motility protein 1 (ELMO1) 3'UTR. Higher ELMO1 expression of AS-MSC is found in vivo in AS patients.
Target Regulation Up regulation
Responsed Disease Ankylosing spondylitis ICD-11: FA92.0Z
 Disease Info 
Pathway Response RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model The SKG mice were randomly divided into three groups: a PBS group, an Av-NC group, and an Av-ELMO1 group. The SKG mice in the Av-ELMO1 group were treated with 5 × 1010 Av-ELMO1 via intravenous tail vein injection at the time of disease induction, and the SKG mice in the Av-NC group or PBS group were separately treated with equal amounts of control adenoviruses or PBS.
Inflammatory spondyloarthritis [ICD-11: FA92]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary TNF-alpha leads to increased expression of ELMO1 in AS-MSC, which is mediated by a METTL14 dependent m6A modification in Engulfment and cell motility protein 1 (ELMO1) 3'UTR. Higher ELMO1 expression of AS-MSC is found in vivo in AS patients.
Responsed Disease Ankylosing spondylitis [ICD-11: FA92.0Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model The SKG mice were randomly divided into three groups: a PBS group, an Av-NC group, and an Av-ELMO1 group. The SKG mice in the Av-ELMO1 group were treated with 5 × 1010 Av-ELMO1 via intravenous tail vein injection at the time of disease induction, and the SKG mice in the Av-NC group or PBS group were separately treated with equal amounts of control adenoviruses or PBS.
References
Ref 1 TNF-Alpha-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis. Nat Commun. 2021 Sep 10;12(1):5373. doi: 10.1038/s41467-021-25710-4.