m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00541)
Target Name Nucleosome-remodeling factor subunit BPTF (BPTF)
Synonyms
Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
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Gene Name BPTF
Chromosomal Location 17q24.2
Family PBTF family
Function
Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex . Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
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Gene ID 2186
Uniprot ID
BPTF_HUMAN
HGNC ID
HGNC:3581
Ensembl Gene ID
ENSG00000171634
KEGG ID
hsa:2186
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
BPTF can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL14-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 9.11E-01
p-value: 2.73E-20
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL14 deficiency promoted RCC metastasis in vitro and in vivo. Mechanistically, METTL14-mediated m6A modification negatively regulated the mRNA stability of Nucleosome-remodeling factor subunit BPTF (BPTF) and depended on BPTF to drive lung metastasis.
Target Regulation Down regulation
Responsed Disease Renal cell carcinoma ICD-11: 2C90
 Disease Info 
Pathway Response Glycerolipid metabolism hsa00561
Cell Process Glycolysis
In-vitro Model RenCa Mouse kidney carcinoma Mus musculus CVCL_2174
Caki-1 Clear cell renal cell carcinoma Homo sapiens CVCL_0234
ACHN Papillary renal cell carcinoma Homo sapiens CVCL_1067
786-O Renal cell carcinoma Homo sapiens CVCL_1051
In-vivo Model To generate a highly metastatic orthotopic xenograft model, 1 × 105 luciferase-expressing Renca cells (Luc-Renca) in 25 ul of 2:1 (v/v) PBS:Matrigel were injected into the right sub-renal capsule of the kidney of BALB/c mice (4 mice/group).
Renal cell carcinoma [ICD-11: 2C90]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL14 deficiency promoted RCC metastasis in vitro and in vivo. Mechanistically, METTL14-mediated m6A modification negatively regulated the mRNA stability of Nucleosome-remodeling factor subunit BPTF (BPTF) and depended on BPTF to drive lung metastasis.
Responsed Disease Renal cell carcinoma [ICD-11: 2C90]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Glycerolipid metabolism hsa00561
Cell Process Glycolysis
In-vitro Model RenCa Mouse kidney carcinoma Mus musculus CVCL_2174
Caki-1 Clear cell renal cell carcinoma Homo sapiens CVCL_0234
ACHN Papillary renal cell carcinoma Homo sapiens CVCL_1067
786-O Renal cell carcinoma Homo sapiens CVCL_1051
In-vivo Model To generate a highly metastatic orthotopic xenograft model, 1 × 105 luciferase-expressing Renca cells (Luc-Renca) in 25 ul of 2:1 (v/v) PBS:Matrigel were injected into the right sub-renal capsule of the kidney of BALB/c mice (4 mice/group).
References
Ref 1 Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma. Theranostics. 2021 Jan 26;11(8):3676-3693. doi: 10.7150/thno.55424. eCollection 2021.