m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00531)
Target Name Protein FAM83D (FAM83D)
Synonyms
Spindle protein CHICA
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Gene Name FAM83D
Chromosomal Location 20q11.23
Family FAM83 family
Function
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
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Gene ID 81610
Uniprot ID
FA83D_HUMAN
HGNC ID
HGNC:16122
Ensembl Gene ID
ENSG00000101447
KEGG ID
hsa:81610
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
FAM83D can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line Human umbilical cord blood CD34+ cells Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells
Control: Wild type UCB CD34+ cells
 GSE107956
Regulation
logFC: 1.01E+00
p-value: 7.31E-07
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between FAM83D and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.69E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF2 inhibits the migration and invasion of lung adenocarcinoma cells by regulating the Protein FAM83D (FAM83D)-TGFbeta1-pSMAD2/3 pathway, which will play an important role in lung cancer metastasis.
Target Regulation Down regulation
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response mRNA surveillance pathway hsa03015
Cell Process Epithelial-mesenchymal transition
In-vitro Model NCI-H1299 Lung large cell carcinoma Homo sapiens CVCL_0060
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF2 inhibits the migration and invasion of lung adenocarcinoma cells by regulating the Protein FAM83D (FAM83D)-TGFbeta1-pSMAD2/3 pathway, which will play an important role in lung cancer metastasis.
Responsed Disease Lung cancer [ICD-11: 2C25]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response mRNA surveillance pathway hsa03015
Cell Process Epithelial-mesenchymal transition
In-vitro Model NCI-H1299 Lung large cell carcinoma Homo sapiens CVCL_0060
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
References
Ref 1 YTHDF2 Inhibits the Migration and Invasion of Lung Adenocarcinoma by Negatively Regulating the FAM83D-TGFBeta1-SMAD2/3 Pathway. Front Oncol. 2022 Feb 2;12:763341. doi: 10.3389/fonc.2022.763341. eCollection 2022.