m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00528)
Target Name Circ_IGF2BP3
Gene Name Circ_IGF2BP3
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_IGF2BP3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In non-small-cell lung carcinoma, METTL3 mediates the N6-methyladenosine (m6A) modification of Circ_IGF2BP3 and promotes its circularization in a manner dependent on the m6A reader protein YTHDC1.
Target Regulation Up regulation
Responsed Disease Non-small-cell lung carcinoma ICD-11: 2C25.Y
 Disease Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
Cell Process Immunity
In-vitro Model SW900 Lung squamous cell carcinoma Homo sapiens CVCL_1731
SK-MES-1 Lung squamous cell carcinoma Homo sapiens CVCL_0630
NCI-H520 Lung squamous cell carcinoma Homo sapiens CVCL_1566
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H1703 Lung squamous cell carcinoma Homo sapiens CVCL_1490
NCI-H1650 Minimally invasive lung adenocarcinoma Homo sapiens CVCL_1483
HEK293T Normal Homo sapiens CVCL_0063
BEAS-2B Normal Homo sapiens CVCL_0168
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
16HBE14o- Normal Homo sapiens CVCL_0112
In-vivo Model A total of 106 LLC cells transfected with the following constructs were injected subcutaneously into C57BL/6 mice.
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary In non-small-cell lung carcinoma, METTL3 mediates the N6-methyladenosine (m6A) modification of Circ_IGF2BP3 and promotes its circularization in a manner dependent on the m6A reader protein YTHDC1.
Target Regulation Up regulation
Responsed Disease Non-small-cell lung carcinoma ICD-11: 2C25.Y
 Disease Info 
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
Cell Process Immunity
In-vitro Model SW900 Lung squamous cell carcinoma Homo sapiens CVCL_1731
SK-MES-1 Lung squamous cell carcinoma Homo sapiens CVCL_0630
NCI-H520 Lung squamous cell carcinoma Homo sapiens CVCL_1566
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H1703 Lung squamous cell carcinoma Homo sapiens CVCL_1490
NCI-H1650 Minimally invasive lung adenocarcinoma Homo sapiens CVCL_1483
HEK293T Normal Homo sapiens CVCL_0063
BEAS-2B Normal Homo sapiens CVCL_0168
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
16HBE14o- Normal Homo sapiens CVCL_0112
In-vivo Model A total of 106 LLC cells transfected with the following constructs were injected subcutaneously into C57BL/6 mice.
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary In non-small-cell lung carcinoma, METTL3 mediates the N6-methyladenosine (m6A) modification of Circ_IGF2BP3 and promotes its circularization in a manner dependent on the m6A reader protein YTHDC1.
Responsed Disease Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
Cell Process Immunity
In-vitro Model SW900 Lung squamous cell carcinoma Homo sapiens CVCL_1731
SK-MES-1 Lung squamous cell carcinoma Homo sapiens CVCL_0630
NCI-H520 Lung squamous cell carcinoma Homo sapiens CVCL_1566
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H1703 Lung squamous cell carcinoma Homo sapiens CVCL_1490
NCI-H1650 Minimally invasive lung adenocarcinoma Homo sapiens CVCL_1483
HEK293T Normal Homo sapiens CVCL_0063
BEAS-2B Normal Homo sapiens CVCL_0168
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
16HBE14o- Normal Homo sapiens CVCL_0112
In-vivo Model A total of 106 LLC cells transfected with the following constructs were injected subcutaneously into C57BL/6 mice.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary In non-small-cell lung carcinoma, METTL3 mediates the N6-methyladenosine (m6A) modification of Circ_IGF2BP3 and promotes its circularization in a manner dependent on the m6A reader protein YTHDC1.
Responsed Disease Non-small-cell lung carcinoma [ICD-11: 2C25.Y]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235
Cell Process Immunity
In-vitro Model SW900 Lung squamous cell carcinoma Homo sapiens CVCL_1731
SK-MES-1 Lung squamous cell carcinoma Homo sapiens CVCL_0630
NCI-H520 Lung squamous cell carcinoma Homo sapiens CVCL_1566
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H1703 Lung squamous cell carcinoma Homo sapiens CVCL_1490
NCI-H1650 Minimally invasive lung adenocarcinoma Homo sapiens CVCL_1483
HEK293T Normal Homo sapiens CVCL_0063
BEAS-2B Normal Homo sapiens CVCL_0168
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
16HBE14o- Normal Homo sapiens CVCL_0112
In-vivo Model A total of 106 LLC cells transfected with the following constructs were injected subcutaneously into C57BL/6 mice.
References
Ref 1 N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021 Aug 20;20(1):105. doi: 10.1186/s12943-021-01398-4.