m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00516)
Target Name C-X-C motif chemokine 11 (CXCL11)
Synonyms
Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
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Gene Name CXCL11
Chromosomal Location 4q21.1
Family Intercrine alpha (chemokine CxC) family
Function
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
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Gene ID 6373
Uniprot ID
CXL11_HUMAN
HGNC ID
HGNC:10638
Ensembl Gene ID
ENSG00000169248
KEGG ID
hsa:6373
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
CXCL11 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA-binding motif protein 15 (RBM15) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary RBM15 enhanced the stability of C-X-C motif chemokine 11 (CXCL11) mRNA in an m6A-dependent manner. These findings highlight the function of RBM15 in ccRCC and reveal a novel identified EP300/CBP-RBM15-CXCL11 signaling axis, which promotes ccRCC progression and provides new insight into ccRCC therapy.
Target Regulation Up regulation
Responsed Disease Renal cell carcinoma of kidney ICD-11: 2C90.0
 Disease Info 
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
HK-2 [Human kidney] Normal Homo sapiens CVCL_0302
Caki-2 Papillary renal cell carcinoma Homo sapiens CVCL_0235
Caki-1 Clear cell renal cell carcinoma Homo sapiens CVCL_0234
786-O Renal cell carcinoma Homo sapiens CVCL_1051
In-vivo Model A total of 5 × 106 786O cells were subcutaneously injected into the left flanks of the mice.
Renal cell carcinoma [ICD-11: 2C90]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary RBM15 enhanced the stability of C-X-C motif chemokine 11 (CXCL11) mRNA in an m6A-dependent manner. These findings highlight the function of RBM15 in ccRCC and reveal a novel identified EP300/CBP-RBM15-CXCL11 signaling axis, which promotes ccRCC progression and provides new insight into ccRCC therapy.
Responsed Disease Renal cell carcinoma of kidney [ICD-11: 2C90.0]
Target Regulator RNA-binding motif protein 15 (RBM15) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
HK-2 [Human kidney] Normal Homo sapiens CVCL_0302
Caki-2 Papillary renal cell carcinoma Homo sapiens CVCL_0235
Caki-1 Clear cell renal cell carcinoma Homo sapiens CVCL_0234
786-O Renal cell carcinoma Homo sapiens CVCL_1051
In-vivo Model A total of 5 × 106 786O cells were subcutaneously injected into the left flanks of the mice.
References
Ref 1 Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11. Free Radic Biol Med. 2022 May 1;184:135-147. doi: 10.1016/j.freeradbiomed.2022.03.031. Epub 2022 Apr 2.