m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00515)
Target Name Polycomb group protein ASXL1 (Asxl1)
Synonyms
Additional sex combs-like protein 1
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Gene Name Asxl1
Chromosomal Location 20q11.21
Family Asx family
Function
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1 . Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing.
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Gene ID 171023
Uniprot ID
ASXL1_HUMAN
HGNC ID
HGNC:18318
Ensembl Gene ID
ENSG00000171456
KEGG ID
hsa:171023
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Asxl1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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YTH domain-containing family protein 3 (YTHDF3) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between Asxl1 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 2.55E+00 GSE86214
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Polycomb group protein ASXL1 (Asxl1) transcripts.
Target Regulation Up regulation
Responsed Disease Neoplasms of haematopoietic or lymphoid tissues ICD-11: 2B3Z
 Disease Info 
Pathway Response mRNA surveillance pathway hsa03015), RNA degradation
Cell Process RNA stability
Neoplasms of haematopoietic or lymphoid tissues [ICD-11: 2B3Z]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Polycomb group protein ASXL1 (Asxl1) transcripts.
Responsed Disease Neoplasms of haematopoietic or lymphoid tissues [ICD-11: 2B3Z]
Target Regulator YTH domain-containing family protein 3 (YTHDF3) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response mRNA surveillance pathway hsa03015), RNA degradation
Cell Process RNA stability
References
Ref 1 m(6)A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts. Haematologica. 2022 Aug 1;107(8):1922-1927. doi: 10.3324/haematol.2021.279300.