m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00512)
Target Name Proliferation-associated protein 2G4 (PA2G4)
Synonyms
Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1
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Gene Name PA2G4
Chromosomal Location 12q13.2
Family Peptidase M24 family
Function
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
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Gene ID 5036
Uniprot ID
PA2G4_HUMAN
HGNC ID
HGNC:8550
Ensembl Gene ID
ENSG00000170515
KEGG ID
hsa:5036
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PA2G4 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Proliferation-associated protein 2G4 (PA2G4) plays a pro-metastatic role by increasing FYN expression through binding with YTHDF2 in HCC. PA2G4 becomes a reliable prognostic marker or therapeutic target for HCC patients.
Target Regulation Up regulation
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12.02
 Disease Info 
Cell Process Cell metastatic
In-vitro Model PLC/PRF/5 Adult hepatocellular carcinoma Homo sapiens CVCL_0485
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
HLF Adult hepatocellular carcinoma Homo sapiens CVCL_2947
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
HEK293T Normal Homo sapiens CVCL_0063
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
In-vivo Model For lung metastasis model, 1 × 106 HCC cells suspended in 100 ul serum free DMEM were injected via the tail vein of nude mice.
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Proliferation-associated protein 2G4 (PA2G4) plays a pro-metastatic role by increasing FYN expression through binding with YTHDF2 in HCC. PA2G4 becomes a reliable prognostic marker or therapeutic target for HCC patients.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell metastatic
In-vitro Model PLC/PRF/5 Adult hepatocellular carcinoma Homo sapiens CVCL_0485
MHCC97-H Adult hepatocellular carcinoma Homo sapiens CVCL_4972
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
HLF Adult hepatocellular carcinoma Homo sapiens CVCL_2947
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
HEK293T Normal Homo sapiens CVCL_0063
HCCLM3 Adult hepatocellular carcinoma Homo sapiens CVCL_6832
In-vivo Model For lung metastasis model, 1 × 106 HCC cells suspended in 100 ul serum free DMEM were injected via the tail vein of nude mice.
References
Ref 1 PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner. Cell Biosci. 2022 May 7;12(1):55. doi: 10.1186/s13578-022-00788-5.