m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00510)
Target Name Krueppel-like factor 12 (KLF12)
Synonyms
Transcriptional repressor AP-2rep
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Gene Name KLF12
Chromosomal Location 13q22.1
Family Sp1 C2H2-type zinc-finger protein family
Function
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
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Gene ID 11278
Uniprot ID
KLF12_HUMAN
HGNC ID
HGNC:6346
Ensembl Gene ID
ENSG00000118922
KEGG ID
hsa:11278
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KLF12 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP2
Cell Line Liver Mus musculus
Treatment: IMP2 -/- liver
Control: Wild type liver cells
 GSE66440
Regulation
logFC: -7.41E-01
p-value: 4.43E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary LncRNA-PACERR which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of Krueppel-like factor 12 (KLF12) and c-myc in cytoplasm. This study found that LncRNA-PACERR functions as key regulator of TAMs in PDAC microenvironment and revealed the novel mechanisms in cytoplasm and in nucleus.
Target Regulation Up regulation
Responsed Disease Pancreatic ductal adenocarcinoma ICD-11: 2C10.0
 Disease Info 
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
PATU-8988 (Human pancreatic adenocarcinoma cell)
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
HEK293T Normal Homo sapiens CVCL_0063
37 (Pancreatic cancer cell)
In-vivo Model BALB/c nude mice which were co-injected with THP-1 cells and PATU-8988 cells subcutaneously.
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary LncRNA-PACERR which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of Krueppel-like factor 12 (KLF12) and c-myc in cytoplasm. This study found that LncRNA-PACERR functions as key regulator of TAMs in PDAC microenvironment and revealed the novel mechanisms in cytoplasm and in nucleus.
Responsed Disease Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
PATU-8988 (Human pancreatic adenocarcinoma cell)
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
HEK293T Normal Homo sapiens CVCL_0063
37 (Pancreatic cancer cell)
In-vivo Model BALB/c nude mice which were co-injected with THP-1 cells and PATU-8988 cells subcutaneously.
References
Ref 1 LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2022 May 7;15(1):52. doi: 10.1186/s13045-022-01272-w.