m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00505)
Target Name Transcription factor HIVEP2 (HIVEP2)
Synonyms
Human immunodeficiency virus type I enhancer-binding protein 2; HIV-EP2; MHC-binding protein 2; MBP-2
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Gene Name HIVEP2
Chromosomal Location 6q24.2
Function
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
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Gene ID 3097
Uniprot ID
ZEP2_HUMAN
HGNC ID
HGNC:4921
Ensembl Gene ID
ENSG00000010818
KEGG ID
hsa:3097
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HIVEP2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line GSC11 cell line Homo sapiens
Treatment: siYTHDF2 GSC11 cells
Control: siControl GSC11 cells
 GSE142825
Regulation
logFC: 1.16E+00
p-value: 1.15E-15
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between HIVEP2 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.70E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF2 facilitates m6A-dependent mRNA decay of LXRA and Transcription factor HIVEP2 (HIVEP2), which impacts the glioma patient survival. YTHDF2 promotes tumorigenesis of GBM cells, largely through the downregulation of LXRA and HIVEP2.
Target Regulation Down regulation
Responsed Disease Glioblastoma ICD-11: 2A00.00
 Disease Info 
Pathway Response mRNA surveillance pathway hsa03015), RNA degradation
Cell Process RNA stability
In-vitro Model U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-251MG Astrocytoma Homo sapiens CVCL_0021
T98G Glioblastoma Homo sapiens CVCL_0556
SW1783 Anaplastic astrocytoma Homo sapiens CVCL_1722
LN-229 Glioblastoma Homo sapiens CVCL_0393
Hs 683 Oligodendroglioma Homo sapiens CVCL_0844
GSC7-2 (GSC7-2 were obtained from fresh surgical specimens of human primary and recurrent glioma)
GSC6-27 (GSC6-27 were obtained from fresh surgical specimens of human primary and recurrent glioma)
GSC23 Glioblastoma Homo sapiens CVCL_DR59
GSC20 (GSC20 were obtained from fresh surgical specimens of human primary and recurrent glioma)
GSC17 Glioblastoma Homo sapiens CVCL_DR57
GSC11 Glioblastoma Homo sapiens CVCL_DR55
In-vivo Model For the studies of investigating mice survival, mice were intracranially injected with 10,000 GSC11, 10,000 GSC7-2, or 500,000 LN229 cells.
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF2 facilitates m6A-dependent mRNA decay of LXRA and Transcription factor HIVEP2 (HIVEP2), which impacts the glioma patient survival. YTHDF2 promotes tumorigenesis of GBM cells, largely through the downregulation of LXRA and HIVEP2.
Responsed Disease Glioblastoma [ICD-11: 2A00.00]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response mRNA surveillance pathway hsa03015), RNA degradation
Cell Process RNA stability
In-vitro Model U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-251MG Astrocytoma Homo sapiens CVCL_0021
T98G Glioblastoma Homo sapiens CVCL_0556
SW1783 Anaplastic astrocytoma Homo sapiens CVCL_1722
LN-229 Glioblastoma Homo sapiens CVCL_0393
Hs 683 Oligodendroglioma Homo sapiens CVCL_0844
GSC7-2 (GSC7-2 were obtained from fresh surgical specimens of human primary and recurrent glioma)
GSC6-27 (GSC6-27 were obtained from fresh surgical specimens of human primary and recurrent glioma)
GSC23 Glioblastoma Homo sapiens CVCL_DR59
GSC20 (GSC20 were obtained from fresh surgical specimens of human primary and recurrent glioma)
GSC17 Glioblastoma Homo sapiens CVCL_DR57
GSC11 Glioblastoma Homo sapiens CVCL_DR55
In-vivo Model For the studies of investigating mice survival, mice were intracranially injected with 10,000 GSC11, 10,000 GSC7-2, or 500,000 LN229 cells.
References
Ref 1 EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nat Commun. 2021 Jan 8;12(1):177. doi: 10.1038/s41467-020-20379-7.