m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00499)
Target Name DNA replication licensing factor MCM4 (MCM4)
Synonyms
CDC21 homolog; P1-CDC21
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Gene Name MCM4
Chromosomal Location 8q11.21
Family MCM family
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
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Gene ID 4173
Uniprot ID
MCM4_HUMAN
HGNC ID
HGNC:6947
Ensembl Gene ID
ENSG00000104738
KEGG ID
hsa:4173
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MCM4 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDC1
Cell Line MOLM-13 cell line Homo sapiens
Treatment: shYTHDC1 MOLM13 cells
Control: shControl MOLM13 cells
 GSE168565
Regulation
logFC: -1.63E+00
p-value: 3.74E-32
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDC1 knockdown has a strong inhibitory effect on proliferation of primary AML cells. YTHDC1 regulates leukemogenesis through DNA replication licensing factor MCM4 (MCM4), which is a critical regulator of DNA replication.
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Pathway Response DNA replication hsa03030
Cell Process DNA replication
Acute myeloid leukaemia [ICD-11: 2A60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDC1 knockdown has a strong inhibitory effect on proliferation of primary AML cells. YTHDC1 regulates leukemogenesis through DNA replication licensing factor MCM4 (MCM4), which is a critical regulator of DNA replication.
Responsed Disease Acute myeloid leukaemia [ICD-11: 2A60]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Pathway Response DNA replication hsa03030
Cell Process DNA replication
References
Ref 1 A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication. Blood. 2021 Dec 30;138(26):2838-2852. doi: 10.1182/blood.2021011707.