m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00489)
Target Name Kinesin-like protein KIF26B (KIF26B)
Gene Name KIF26B
Family TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00283}.
Function
Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.
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Gene ID 26574
Uniprot ID
KI26B_HUMAN
HGNC ID
HGNC:25484
Ensembl Gene ID
ENSG00000162849
KEGG ID
hsa:55083
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KIF26B can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Zinc finger CCCH domain-containing protein 13 (ZC3H13) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ZC3H13
Cell Line mouse embryonic stem cells Mus musculus
Treatment: ZC3H13-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 7.11E-01
p-value: 3.34E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Ginsenoside Rh2 reduces m6A RNA methylation via downregulating KIF26B expression in some cancer cells. KIF26B elevates m6A RNA methylation via enhancing ZC3H13/CBLL1 nuclear localization. KIF26B-SRF forms a positive feedback loop facilitating tumor growth.
Responsed Disease Solid tumour/cancer ICD-11: 2A00-2F9Z
 Disease Info 
In-vitro Model SK-LMS-1 Vulvar leiomyosarcoma Homo sapiens CVCL_0628
MDA-MB-157 Breast carcinoma Homo sapiens CVCL_0618
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
In-vivo Model BALB/c nude mice (5 weeks old) were purchased from the Beijing HFK Bioscience Co. Ltd. 2×106 cells (50 uL) were mixed with 50 uL Matrigel (BD Biosciences, San Jose, CA, USA) were injected subcutaneously in the rear flank fat pad of the nude mice (N = 6, per group).
E3 ubiquitin-protein ligase Hakai (CBLL1) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Ginsenoside Rh2 reduces m6A RNA methylation via downregulating KIF26B expression in some cancer cells. KIF26B elevates m6A RNA methylation via enhancing ZC3H13/CBLL1 nuclear localization. KIF26B-SRF forms a positive feedback loop facilitating tumor growth.
Responsed Disease Solid tumour/cancer ICD-11: 2A00-2F9Z
 Disease Info 
In-vitro Model SK-LMS-1 Vulvar leiomyosarcoma Homo sapiens CVCL_0628
MDA-MB-157 Breast carcinoma Homo sapiens CVCL_0618
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
In-vivo Model BALB/c nude mice (5 weeks old) were purchased from the Beijing HFK Bioscience Co. Ltd. 2×106 cells (50 uL) were mixed with 50 uL Matrigel (BD Biosciences, San Jose, CA, USA) were injected subcutaneously in the rear flank fat pad of the nude mice (N = 6, per group).
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Ginsenoside Rh2 reduces m6A RNA methylation via downregulating KIF26B expression in some cancer cells. KIF26B elevates m6A RNA methylation via enhancing ZC3H13/CBLL1 nuclear localization. KIF26B-SRF forms a positive feedback loop facilitating tumor growth.
Responsed Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Target Regulator E3 ubiquitin-protein ligase Hakai (CBLL1) WRITER
 Regulator Info 
In-vitro Model SK-LMS-1 Vulvar leiomyosarcoma Homo sapiens CVCL_0628
MDA-MB-157 Breast carcinoma Homo sapiens CVCL_0618
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
In-vivo Model BALB/c nude mice (5 weeks old) were purchased from the Beijing HFK Bioscience Co. Ltd. 2×106 cells (50 uL) were mixed with 50 uL Matrigel (BD Biosciences, San Jose, CA, USA) were injected subcutaneously in the rear flank fat pad of the nude mice (N = 6, per group).
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Ginsenoside Rh2 reduces m6A RNA methylation via downregulating KIF26B expression in some cancer cells. KIF26B elevates m6A RNA methylation via enhancing ZC3H13/CBLL1 nuclear localization. KIF26B-SRF forms a positive feedback loop facilitating tumor growth.
Responsed Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Target Regulator Zinc finger CCCH domain-containing protein 13 (ZC3H13) WRITER
 Regulator Info 
In-vitro Model SK-LMS-1 Vulvar leiomyosarcoma Homo sapiens CVCL_0628
MDA-MB-157 Breast carcinoma Homo sapiens CVCL_0618
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
In-vivo Model BALB/c nude mice (5 weeks old) were purchased from the Beijing HFK Bioscience Co. Ltd. 2×106 cells (50 uL) were mixed with 50 uL Matrigel (BD Biosciences, San Jose, CA, USA) were injected subcutaneously in the rear flank fat pad of the nude mice (N = 6, per group).
References
Ref 1 Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop. J Ginseng Res. 2021 Nov;45(6):734-743. doi: 10.1016/j.jgr.2021.05.004. Epub 2021 May 25.