m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00461)
Target Name Serum response factor (SRF)
Synonyms
SRF
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Gene Name SRF
Function
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}.
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Gene ID 5395
Uniprot ID
SRF_HUMAN
HGNC ID
HGNC:11291
Ensembl Gene ID
ENSG00000112658
KEGG ID
hsa:6722
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SRF can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP1
Cell Line MV3 cell line Homo sapiens
Treatment: siIGF2BP1 MV3 cells
Control: siControl MV3 cells
 GSE146803
Regulation
logFC: -9.12E-01
p-value: 4.27E-10
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary IGF2BP1 promotes Serum response factor (SRF) and SRF target genes at the post-transcriptional level suggesting it as a post-transcriptional enhancer of SRF itself as well as SRF-dependent gene expression in cancer cells.
Target Regulation Up regulation
Responsed Disease Solid tumour/cancer ICD-11: 2A00-2F9Z
 Disease Info 
Cell Process Cell growth
Cell invasion
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary IGF2BP1 promotes Serum response factor (SRF) and SRF target genes at the post-transcriptional level suggesting it as a post-transcriptional enhancer of SRF itself as well as SRF-dependent gene expression in cancer cells.
Responsed Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell growth
Cell invasion
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
K-562 Chronic myelogenous leukemia Homo sapiens CVCL_0004
References
Ref 1 IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner. Nucleic Acids Res. 2019 Jan 10;47(1):375-390. doi: 10.1093/nar/gky1012.