m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00449)
Target Name Vacuolar protein-sorting-associated protein 25 (VPS25)
Synonyms
hVps25; Dermal papilla-derived protein 9; ELL-associated protein of 20 kDa; ESCRT-II complex subunit VPS25; DERP9; EAP20
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Gene Name VPS25
Chromosomal Location 17q21.31
Family VPS25 family
Function
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
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Gene ID 84313
Uniprot ID
VPS25_HUMAN
HGNC ID
HGNC:28122
Ensembl Gene ID
ENSG00000131475
KEGG ID
hsa:84313
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
VPS25 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDC1 inhibited glioma proliferation by reducing the expression of Vacuolar protein-sorting-associated protein 25 (VPS25).
Target Regulation Down regulation
Responsed Disease Glioma ICD-11: 2A00.0
 Disease Info 
Pathway Response JAK-STAT signaling pathway hsa04630
Cell Process Arrest cell cycle at G0/G1 phase
Cell apoptosis
In-vitro Model U251 (Fibroblasts or fibroblast like cells)
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
In-vivo Model The U87MG cells (1 × 107 cells in 0.1 ml PBS) were injected subcutaneously into BALB/c nude mice. Tumor width and length were recorded every 5 days.
Brain cancer [ICD-11: 2A00]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDC1 inhibited glioma proliferation by reducing the expression of Vacuolar protein-sorting-associated protein 25 (VPS25).
Responsed Disease Glioma [ICD-11: 2A00.0]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response JAK-STAT signaling pathway hsa04630
Cell Process Arrest cell cycle at G0/G1 phase
Cell apoptosis
In-vitro Model U251 (Fibroblasts or fibroblast like cells)
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
In-vivo Model The U87MG cells (1 × 107 cells in 0.1 ml PBS) were injected subcutaneously into BALB/c nude mice. Tumor width and length were recorded every 5 days.
References
Ref 1 YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells. Cancer Cell Int. 2021 Dec 4;21(1):645. doi: 10.1186/s12935-021-02304-0.