m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00426)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TFEB
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | LNCaP cell line | Homo sapiens |
Treatment: shMETTL3 LNCaP cells
Control: shControl LNCaP cells
|
GSE147884 | |
Regulation |
|
logFC: -6.54E-01 p-value: 8.08E-07 |
More Results | Click to View More RNA-seq Results | |
Representative RIP-seq result supporting the interaction between TFEB and the regulator | ||
Cell Line | MDA-MB-231 | Homo sapiens |
Regulation | logFC: 8.22E+00 | GSE60213 |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | METTL3 methylates Transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy genes, at two m6A residues in the 3'-UTR, which promotes the association of the RNA-binding protein HNRNPD with TFEB pre-mRNA and subsequently decreases the expression levels of TFEB. METTL3-ALKBH5 and autophagy, providing insight into the functional importance of the reversible mRNA m6A methylation and its modulators in ischemic heart disease. | |||
Target Regulation | Down regulation | |||
Responsed Disease | Ischemic heart disease | ICD-11: BA40-BA6Z | ||
Pathway Response | Apoptosis | hsa04210) | ||
Cell Process | Cell proliferation | |||
In-vitro Model | H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 |
HEK293T | Normal | Homo sapiens | CVCL_0063 | |
In-vivo Model | To cause I/R injury, mice were subjected to 30 min of LAD ischemia followed by 60 min of reperfusion. | |||
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5 | ||
Cell Line | THP1 cell line | Homo sapiens |
Treatment: ALKBH5 knockdown THP1 cells
Control: Wild type THP1 cells
|
GSE128574 | |
Regulation |
|
logFC: -1.28E+00 p-value: 2.60E-04 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | METTL3 methylates Transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy genes, at two m6A residues in the 3'-UTR, which promotes the association of the RNA-binding protein HNRNPD with TFEB pre-mRNA and subsequently decreases the expression levels of TFEB. METTL3-ALKBH5 and autophagy, providing insight into the functional importance of the reversible mRNA m6A methylation and its modulators in ischemic heart disease. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Ischemic heart disease | ICD-11: BA40-BA6Z | ||
Pathway Response | Apoptosis | hsa04210) | ||
Cell Process | Cell proliferation | |||
In-vitro Model | H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 |
HEK293T | Normal | Homo sapiens | CVCL_0063 | |
In-vivo Model | To cause I/R injury, mice were subjected to 30 min of LAD ischemia followed by 60 min of reperfusion. | |||
Ischemic heart disease [ICD-11: BA40-BA6Z]
In total 2 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | METTL3 methylates Transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy genes, at two m6A residues in the 3'-UTR, which promotes the association of the RNA-binding protein HNRNPD with TFEB pre-mRNA and subsequently decreases the expression levels of TFEB. METTL3-ALKBH5 and autophagy, providing insight into the functional importance of the reversible mRNA m6A methylation and its modulators in ischemic heart disease. | |||
Responsed Disease | Ischemic heart disease [ICD-11: BA40-BA6Z] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Down regulation | |||
Pathway Response | Apoptosis | hsa04210) | ||
Cell Process | Cell proliferation | |||
In-vitro Model | H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 |
HEK293T | Normal | Homo sapiens | CVCL_0063 | |
In-vivo Model | To cause I/R injury, mice were subjected to 30 min of LAD ischemia followed by 60 min of reperfusion. | |||
Experiment 2 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | METTL3 methylates Transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy genes, at two m6A residues in the 3'-UTR, which promotes the association of the RNA-binding protein HNRNPD with TFEB pre-mRNA and subsequently decreases the expression levels of TFEB. METTL3-ALKBH5 and autophagy, providing insight into the functional importance of the reversible mRNA m6A methylation and its modulators in ischemic heart disease. | |||
Responsed Disease | Ischemic heart disease [ICD-11: BA40-BA6Z] | |||
Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
Target Regulation | Up regulation | |||
Pathway Response | Apoptosis | hsa04210) | ||
Cell Process | Cell proliferation | |||
In-vitro Model | H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 |
HEK293T | Normal | Homo sapiens | CVCL_0063 | |
In-vivo Model | To cause I/R injury, mice were subjected to 30 min of LAD ischemia followed by 60 min of reperfusion. | |||