m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00415)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SRSF11
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | Liver | Mus musculus |
Treatment: Mettl3 knockout liver
Control: Wild type liver cells
|
GSE198512 | |
Regulation |
|
logFC: -6.30E-01 p-value: 2.77E-03 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Silencing METTL3 or overexpressing dominant-negative mutant METTL3 suppressed the growth and self-renewal of Glioblastoma cells. Integrated transcriptome and MeRIP-seq analyses revealed that downregulating the expression of METTL3 decreased m6A modification levels of Serine/arginine-rich splicing factor 11 (SRSF11), which led to YTHDC1-dependent NMD of SRSF transcripts and decreased SRSF protein expression. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Glioblastoma | ICD-11: 2A00.00 | ||
Pathway Response | RNA degradation | hsa03018 | ||
Cell Process | mRNA decay | |||
In-vitro Model | U251 (Fibroblasts or fibroblast like cells) | |||
U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 | |
In-vivo Model | For subcutaneous tumor model, each mouse was injected subcutaneously in the right flank with 2 × 106 U87MG cells (METTL3-KD or control) in 100 uL PBS. | |||
YTH domain-containing protein 1 (YTHDC1) [READER]
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDC1 | ||
Cell Line | ICM cell line | Mus musculus |
Treatment: YTHDC1 knockout ICM cells
Control: Wild type ICM cells
|
GSE157267 | |
Regulation |
|
logFC: -2.75E+00 p-value: 7.07E-03 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Silencing METTL3 or overexpressing dominant-negative mutant METTL3 suppressed the growth and self-renewal of Glioblastoma cells. Integrated transcriptome and MeRIP-seq analyses revealed that downregulating the expression of METTL3 decreased m6A modification levels of Serine/arginine-rich splicing factor 11 (SRSF11), which led to YTHDC1-dependent NMD of SRSF transcripts and decreased SRSF protein expression. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Glioblastoma | ICD-11: 2A00.00 | ||
Pathway Response | RNA degradation | hsa03018 | ||
Cell Process | mRNA decay | |||
In-vitro Model | U251 (Fibroblasts or fibroblast like cells) | |||
U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 | |
In-vivo Model | For subcutaneous tumor model, each mouse was injected subcutaneously in the right flank with 2 × 106 U87MG cells (METTL3-KD or control) in 100 uL PBS. | |||
Brain cancer [ICD-11: 2A00]
In total 2 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Silencing METTL3 or overexpressing dominant-negative mutant METTL3 suppressed the growth and self-renewal of Glioblastoma cells. Integrated transcriptome and MeRIP-seq analyses revealed that downregulating the expression of METTL3 decreased m6A modification levels of Serine/arginine-rich splicing factor 11 (SRSF11), which led to YTHDC1-dependent NMD of SRSF transcripts and decreased SRSF protein expression. | |||
Responsed Disease | Glioblastoma [ICD-11: 2A00.00] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Pathway Response | RNA degradation | hsa03018 | ||
Cell Process | mRNA decay | |||
In-vitro Model | U251 (Fibroblasts or fibroblast like cells) | |||
U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 | |
In-vivo Model | For subcutaneous tumor model, each mouse was injected subcutaneously in the right flank with 2 × 106 U87MG cells (METTL3-KD or control) in 100 uL PBS. | |||
Experiment 2 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Silencing METTL3 or overexpressing dominant-negative mutant METTL3 suppressed the growth and self-renewal of Glioblastoma cells. Integrated transcriptome and MeRIP-seq analyses revealed that downregulating the expression of METTL3 decreased m6A modification levels of Serine/arginine-rich splicing factor 11 (SRSF11), which led to YTHDC1-dependent NMD of SRSF transcripts and decreased SRSF protein expression. | |||
Responsed Disease | Glioblastoma [ICD-11: 2A00.00] | |||
Target Regulator | YTH domain-containing protein 1 (YTHDC1) | READER | ||
Target Regulation | Up regulation | |||
Pathway Response | RNA degradation | hsa03018 | ||
Cell Process | mRNA decay | |||
In-vitro Model | U251 (Fibroblasts or fibroblast like cells) | |||
U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 | |
In-vivo Model | For subcutaneous tumor model, each mouse was injected subcutaneously in the right flank with 2 × 106 U87MG cells (METTL3-KD or control) in 100 uL PBS. | |||