m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00392)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SIAH1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) [READER]
Representative RNA-seq result indicating the expression of this target gene regulated by HNRNPA2B1 | ||
Cell Line | c2c12 cell line | Mus musculus |
Treatment: HNRNPA2B1 knockout c2c12 cells
Control: WT c2c12 cells
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GSE152467 | |
Regulation |
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logFC: 1.19E+00 p-value: 5.63E-11 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | The RP11/hnRNPA2B1/mRNA complex accelerated the mRNA degradation of two E3 ligases, E3 ubiquitin-protein ligase SIAH1 (SIAH1) and Fbxo45, and subsequently prevented the proteasomal degradation of Zeb1. m6A can regulate the expression of RP11, further, RP11 regulated Siah1-Fbxo45/Zeb1 was involved in the development of Colorectal cancer. | |||
Target Regulation | Down regulation | |||
Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
Pathway Response | Proteasome | hsa03050 | ||
Cell Process | Proteasomal degradation | |||
In-vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 |
HCT 15 | Colon adenocarcinoma | Homo sapiens | CVCL_0292 | |
HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
RKO | Colon carcinoma | Homo sapiens | CVCL_0504 | |
SW480 | Colon adenocarcinoma | Homo sapiens | CVCL_0546 | |
In-vivo Model | HCT-15 RP11 stable overexpression or control cells (2 × 106 per mouse) diluted in 100 uL normal medium + 100 uL Matrigel (BD Biosciences) were subcutaneously injected into immunodeficient mice to investigate tumour growth. | |||
Colorectal cancer [ICD-11: 2B91]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | The RP11/hnRNPA2B1/mRNA complex accelerated the mRNA degradation of two E3 ligases, E3 ubiquitin-protein ligase SIAH1 (SIAH1) and Fbxo45, and subsequently prevented the proteasomal degradation of Zeb1. m6A can regulate the expression of RP11, further, RP11 regulated Siah1-Fbxo45/Zeb1 was involved in the development of Colorectal cancer. | |||
Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
Target Regulator | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | READER | ||
Target Regulation | Down regulation | |||
Pathway Response | Proteasome | hsa03050 | ||
Cell Process | Proteasomal degradation | |||
In-vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 |
HCT 15 | Colon adenocarcinoma | Homo sapiens | CVCL_0292 | |
HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
RKO | Colon carcinoma | Homo sapiens | CVCL_0504 | |
SW480 | Colon adenocarcinoma | Homo sapiens | CVCL_0546 | |
In-vivo Model | HCT-15 RP11 stable overexpression or control cells (2 × 106 per mouse) diluted in 100 uL normal medium + 100 uL Matrigel (BD Biosciences) were subcutaneously injected into immunodeficient mice to investigate tumour growth. | |||