m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00382)
Target Name E3 SUMO-protein ligase RanBP2 (RANBP2)
Synonyms
358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270; NUP358
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Gene Name RANBP2
Chromosomal Location 2q13
Family RanBP2 E3 ligase family
Function
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle . Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
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Gene ID 5903
Uniprot ID
RBP2_HUMAN
HGNC ID
HGNC:9848
Ensembl Gene ID
ENSG00000153201
KEGG ID
hsa:5903
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
RANBP2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 1 (YTHDF1) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between RANBP2 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 2.70E+00 GSE63591
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The oncogenic role of YTHDF1 in cervical cancer by regulating E3 SUMO-protein ligase RanBP2 (RANBP2) expression and YTHDF1 represents a potential target for cervical cancer therapy.
Target Regulation Up regulation
Responsed Disease Cervical cancer ICD-11: 2C77
 Disease Info 
Cell Process Cell growth
Cell migration
Cell invasion
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
In-vivo Model Balb/c female nude mice at 4-6 weeks old were injected with 4 × 106 cells subcutaneously on the back.
Cervical cancer [ICD-11: 2C77]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The oncogenic role of YTHDF1 in cervical cancer by regulating E3 SUMO-protein ligase RanBP2 (RANBP2) expression and YTHDF1 represents a potential target for cervical cancer therapy.
Responsed Disease Cervical cancer [ICD-11: 2C77]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell growth
Cell migration
Cell invasion
In-vitro Model HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
In-vivo Model Balb/c female nude mice at 4-6 weeks old were injected with 4 × 106 cells subcutaneously on the back.
References
Ref 1 YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2. Front Oncol. 2021 Mar 19;11:650383. doi: 10.3389/fonc.2021.650383. eCollection 2021.