m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00379)
Target Name GTPase KRas (KRAS)
Synonyms
K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; KRAS2; RASK2
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Gene Name KRAS
Chromosomal Location 12p12.1
Family small GTPase superfamily; Ras family
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
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Gene ID 3845
Uniprot ID
RASK_HUMAN
HGNC ID
HGNC:6407
Ensembl Gene ID
ENSG00000133703
KEGG ID
hsa:3845
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KRAS can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary UCA1 increases GTPase KRas (KRAS) phosphorylation by interacting with hnRNPA2B1 and that UCA1 functions as a molecular sponge for miR-590-3p to promote KRAS expression. the UCA1-KRAS axis plays a crucial role in pancreatic ductal adenocarcinoma progression and that UCA1 serves as a target for new PDAC therapies.
Target Regulation Up regulation
Responsed Disease Pancreatic ductal adenocarcinoma ICD-11: 2C10.0
 Disease Info 
Pathway Response Ras signaling pathway hsa04014
In-vitro Model HPDE6c7 Normal Homo sapiens CVCL_0P38
HEK293T Normal Homo sapiens CVCL_0063
HPAF-II Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0313
MPanc-96 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_7165
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
PaTu 8902 Pancreatic adenocarcinoma Homo sapiens CVCL_1845
PaTu 8988s Pancreatic adenocarcinoma Homo sapiens CVCL_1846
SW1990 Pancreatic adenocarcinoma Homo sapiens CVCL_1723
In-vivo Model HPAF-II cells (2.0 × 106 cells/site) stably transfected with sh-EGFP or sh-UCA1 were subcutaneously injected into 4-week-old nude mice to generate xenografts. The tumor volume was measured every week after injection and calculated using the following formula: length × (width2)/2.
Pancreatic cancer [ICD-11: 2C10]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary UCA1 increases GTPase KRas (KRAS) phosphorylation by interacting with hnRNPA2B1 and that UCA1 functions as a molecular sponge for miR-590-3p to promote KRAS expression. the UCA1-KRAS axis plays a crucial role in pancreatic ductal adenocarcinoma progression and that UCA1 serves as a target for new PDAC therapies.
Responsed Disease Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]
Target Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Ras signaling pathway hsa04014
In-vitro Model HPDE6c7 Normal Homo sapiens CVCL_0P38
HEK293T Normal Homo sapiens CVCL_0063
HPAF-II Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0313
MPanc-96 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_7165
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens CVCL_0480
PaTu 8902 Pancreatic adenocarcinoma Homo sapiens CVCL_1845
PaTu 8988s Pancreatic adenocarcinoma Homo sapiens CVCL_1846
SW1990 Pancreatic adenocarcinoma Homo sapiens CVCL_1723
In-vivo Model HPAF-II cells (2.0 × 106 cells/site) stably transfected with sh-EGFP or sh-UCA1 were subcutaneously injected into 4-week-old nude mice to generate xenografts. The tumor volume was measured every week after injection and calculated using the following formula: length × (width2)/2.
References
Ref 1 The UCA1/KRAS axis promotes human pancreatic ductal adenocarcinoma stem cell properties and tumor growth. Am J Cancer Res. 2019 Mar 1;9(3):496-510. eCollection 2019.