m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00357)
Target Name Tumor protein 63 (TP63)
Synonyms
p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51; KET; P63; P73H; P73L; TP73L
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Gene Name TP63
Chromosomal Location 3q28
Family p53 family
Function
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
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Gene ID 8626
Uniprot ID
P63_HUMAN
HGNC ID
HGNC:15979
Ensembl Gene ID
ENSG00000073282
KEGG ID
hsa:8626
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TP63 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL3-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 4.35E+00
p-value: 1.15E-34
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between TP63 and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 6.67E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 knock down and methylation inhibitor cycloleucine could decrease the m6A levels and the expression of DeltaNp63 in Cutaneous squamous cell carcinoma.
Target Regulation Up regulation
Responsed Disease Cutaneous squamous cell carcinoma ICD-11: 2C31.Z
 Disease Info 
Pathway Response Signaling pathways regulating pluripotency of stem cells hsa04550
Cell Process Cell proliferation
In-vitro Model A-431 Skin squamous cell carcinoma Homo sapiens CVCL_0037
HSC-1 Skin squamous cell carcinoma Homo sapiens CVCL_2807
In-vivo Model 2 × 106 cells were suspended in 150 uL DMEM. The A431 cells (scrambled group and shRNA1 group) were injected subcutaneously into the flanks of nude mice.
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary In lung squamous cell carcinoma, seven m6A-related autophagy genes were screened to construct a prognostic model: CASP4, CDKN1A, DLC1, ITGB1, PINK1, Tumor protein 63 (TP63), and EIF4EBP1.
Responsed Disease Lung squamous cell carcinoma [ICD-11: 2C25.2]
Pathway Response Autophagy hsa04140
Cell Process Cell proliferation and metastasis
Cell autophagy
Cutaneous squamous cell carcinoma [ICD-11: 2C31]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 knock down and methylation inhibitor cycloleucine could decrease the m6A levels and the expression of DeltaNp63 in Cutaneous squamous cell carcinoma.
Responsed Disease Cutaneous squamous cell carcinoma [ICD-11: 2C31.Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Signaling pathways regulating pluripotency of stem cells hsa04550
Cell Process Cell proliferation
In-vitro Model A-431 Skin squamous cell carcinoma Homo sapiens CVCL_0037
HSC-1 Skin squamous cell carcinoma Homo sapiens CVCL_2807
In-vivo Model 2 × 106 cells were suspended in 150 uL DMEM. The A431 cells (scrambled group and shRNA1 group) were injected subcutaneously into the flanks of nude mice.
References
Ref 1 METTL3 mediated m(6)A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating DeltaNp63. Biochem Biophys Res Commun. 2019 Jul 23;515(2):310-317. doi: 10.1016/j.bbrc.2019.05.155. Epub 2019 May 29.