m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0035)
Name
Cutaneous squamous cell carcinoma
ICD
ICD-11: 2C31
Full List of Target Gene(s) of This m6A-centered Disease Response
Tumor protein 63 (TP63)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL3 knock down and methylation inhibitor cycloleucine could decrease the m6A levels and the expression of DeltaNp63 in Cutaneous squamous cell carcinoma.
Responsed Disease Cutaneous squamous cell carcinoma [ICD-11: 2C31.Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Signaling pathways regulating pluripotency of stem cells hsa04550
Cell Process Cell proliferation
In-vitro Model A-431 Skin squamous cell carcinoma Homo sapiens CVCL_0037
HSC-1 Skin squamous cell carcinoma Homo sapiens CVCL_2807
In-vivo Model 2 × 106 cells were suspended in 150 uL DMEM. The A431 cells (scrambled group and shRNA1 group) were injected subcutaneously into the flanks of nude mice.
References
Ref 1 METTL3 mediated m(6)A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating DeltaNp63. Biochem Biophys Res Commun. 2019 Jul 23;515(2):310-317. doi: 10.1016/j.bbrc.2019.05.155. Epub 2019 May 29.