m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00355)
Target Name Oxidative stress-induced growth inhibitor 1 (OSGIN1)
Synonyms
Bone marrow stromal cell-derived growth inhibitor; BMSC-derived growth inhibitor; Ovary, kidney and liver protein 38; huOKL38; Pregnancy-induced growth inhibitor OKL38; BDGI; OKL38
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Gene Name OSGIN1
Chromosomal Location 16q23.3
Family OKL38 family
Function
Regulates the differentiation and proliferation through the regulation of cell death.
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Gene ID 29948
Uniprot ID
OSGI1_HUMAN
HGNC ID
HGNC:30093
Ensembl Gene ID
ENSG00000140961
KEGG ID
hsa:29948
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
OSGIN1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Liver Mus musculus
Treatment: Mettl3 knockout liver
Control: Wild type liver cells
 GSE198513
Regulation
logFC: -1.34E+00
p-value: 4.00E-87
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 regulates PM 2.5-induced cell injury by targeting Oxidative stress-induced growth inhibitor 1 (OSGIN1) in human airway epithelial cells.
Target Regulation Up regulation
Responsed Disease Trachea cancer ICD-11: 2C24
 Disease Info 
Cell Process Cell injury
Cell apoptosis
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
Trachea cancer [ICD-11: 2C24]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 regulates PM 2.5-induced cell injury by targeting Oxidative stress-induced growth inhibitor 1 (OSGIN1) in human airway epithelial cells.
Responsed Disease Trachea cancer [ICD-11: 2C24]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell injury
Cell apoptosis
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
References
Ref 1 METTL3 regulates PM(2.5)-induced cell injury by targeting OSGIN1 in human airway epithelial cells. J Hazard Mater. 2021 Aug 5;415:125573. doi: 10.1016/j.jhazmat.2021.125573. Epub 2021 Mar 3.