m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00336)
Target Name MOB kinase activator 3B (MOB3B)
Synonyms
Mob1 homolog 2b; Mps one binder kinase activator-like 2B; MOB kinase activator-like 2B; C9orf35; MOBKL2B
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Gene Name MOB3B
Chromosomal Location 9p21.2
Family MOB1/phocein family
Function
Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
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Gene ID 79817
Uniprot ID
MOB3B_HUMAN
HGNC ID
HGNC:23825
Ensembl Gene ID
ENSG00000120162
KEGG ID
hsa:79817
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MOB3B can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line GSC11 cell line Homo sapiens
Treatment: siYTHDF2 GSC11 cells
Control: siControl GSC11 cells
 GSE142825
Regulation
logFC: -6.21E-01
p-value: 1.40E-08
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between MOB3B and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.42E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression. YTHDF2 could inhibit MOB kinase activator 3B (MOB3B) expression by recognizing m6A modification of MOB3B mRNA and inducing mRNA degradation.
Target Regulation Down regulation
Responsed Disease Prostate cancer ICD-11: 2C82
 Disease Info 
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell apoptosis
In-vitro Model DU145 Prostate carcinoma Homo sapiens CVCL_0105
LNCaP C4-2 Prostate carcinoma Homo sapiens CVCL_4782
PC-3 Prostate carcinoma Homo sapiens CVCL_0035
In-vivo Model Under anesthesia with ether, the nude mice were disinfected and subcutaneously inoculated with cells transfected with oe-NC, oe-KDM5A + oe-NC and oe-KDM5A + oe-MOB3B at a density of 1 × 106 cells/mouse (200 uL) at the back of the right hind leg.
Prostate cancer [ICD-11: 2C82]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression. YTHDF2 could inhibit MOB kinase activator 3B (MOB3B) expression by recognizing m6A modification of MOB3B mRNA and inducing mRNA degradation.
Responsed Disease Prostate cancer [ICD-11: 2C82]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell apoptosis
In-vitro Model DU145 Prostate carcinoma Homo sapiens CVCL_0105
LNCaP C4-2 Prostate carcinoma Homo sapiens CVCL_4782
PC-3 Prostate carcinoma Homo sapiens CVCL_0035
In-vivo Model Under anesthesia with ether, the nude mice were disinfected and subcutaneously inoculated with cells transfected with oe-NC, oe-KDM5A + oe-NC and oe-KDM5A + oe-MOB3B at a density of 1 × 106 cells/mouse (200 uL) at the back of the right hind leg.
References
Ref 1 Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression. J Exp Clin Cancer Res. 2020 Oct 21;39(1):223. doi: 10.1186/s13046-020-01735-3.