m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00303)
Target Name Adenylate kinase 4, mitochondrial (AK4)
Synonyms
AK 4; Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4; AK3; AK3L1
    Click to Show/Hide
Gene Name AK4
Chromosomal Location 1p31.3
Family adenylate kinase family; AK3 subfamily
Function
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress.
    Click to Show/Hide
Gene ID 205
Uniprot ID
KAD4_HUMAN
HGNC ID
HGNC:363
Ensembl Gene ID
ENSG00000162433
KEGG ID
hsa:205
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
AK4 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Browse Drug
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: -5.87E-01
p-value: 2.40E-51
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Adenylate kinase 4 modulates the resistance of breast cancer cells to tamoxifen through an m6A-based epitranscriptomic mechanism. Genetic depletion of METTL3 in TamR MCF-7 cells led to a diminished Adenylate kinase 4, mitochondrial (AK4) protein level and attenuated resistance to tamoxifen.
Target Regulation Up regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Responsed Drug Tamoxifen Approved
 Drug Info 
Cell Process Mitochondrial apoptosis
In-vitro Model MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MCF7-TamR Invasive breast carcinoma Homo sapiens CVCL_EG55
Breast cancer [ICD-11: 2C60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Adenylate kinase 4 modulates the resistance of breast cancer cells to tamoxifen through an m6A-based epitranscriptomic mechanism. Genetic depletion of METTL3 in TamR MCF-7 cells led to a diminished Adenylate kinase 4, mitochondrial (AK4) protein level and attenuated resistance to tamoxifen.
Responsed Disease Breast cancer [ICD-11: 2C60]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Drug Tamoxifen Approved
 Drug Info 
Cell Process Mitochondrial apoptosis
In-vitro Model MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MCF7-TamR Invasive breast carcinoma Homo sapiens CVCL_EG55
Tamoxifen [Approved]
 Drug Info 
In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response [1]
Response Summary Adenylate kinase 4 modulates the resistance of breast cancer cells to tamoxifen through an m6A-based epitranscriptomic mechanism. Genetic depletion of METTL3 in TamR MCF-7 cells led to a diminished Adenylate kinase 4, mitochondrial (AK4) protein level and attenuated resistance to tamoxifen.
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Cell Process Mitochondrial apoptosis
In-vitro Model MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MCF7-TamR Invasive breast carcinoma Homo sapiens CVCL_EG55
References
Ref 1 Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism. Mol Ther. 2020 Dec 2;28(12):2593-2604. doi: 10.1016/j.ymthe.2020.09.007. Epub 2020 Sep 5.